| Symptom-based diagnosis of malaria and its implication on antimalarial drug use in pregnancy in Central Uganda: results from a community trial. | |
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MedLine Citation:
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PMID: 21061926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Data on malaria morbidity and treatment seeking practices were collected from pregnant women as part of a community intervention study testing new approaches to deliver intermittent preventive treatment of malaria in pregnancy in Mukono district, central Uganda. RESULTS: A high proportion of pregnant women, 261/667 (39.1%) at the health units reported having fever; and of these 124/559 (22.2%) had positive smears for Plasmodium faciliparum. The symptom-based approach had a low sensitivity of 26.4%, leading to many pregnant women with malaria undiagnosed. Similarly, a high proportion of pregnant women, 145/383 (37.9%) with negative blood smears for P. falciparum received antimalarial drugs in addition to intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine (SP). CONCLUSION: The results call for urgent strategies to identify effective diagnostic tools for malaria in pregnancy and to assess the negative effects of the over-use of antimalarial drugs in pregnancy. |
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Authors:
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Anthony K Mbonye; Pascal Magnussen |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of adolescent medicine and health Volume: 22 ISSN: 0334-0139 ISO Abbreviation: Int J Adolesc Med Health Publication Date: 2010 Apr-Jun |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506960 Medline TA: Int J Adolesc Med Health Country: England |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Community Health, Ministry of Health, Box 7272, Kampala, Uganda. vpadmn@infocom.co.ug |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antimalarials* Chemoprevention Child Drug Combinations Female Humans Inappropriate Prescribing Malaria, Falciparum / drug therapy, prevention & control* Mass Screening / methods* Middle Aged Pregnancy Pregnancy Complications, Infectious / drug therapy, parasitology, prevention & control* Pyrimethamine* Sensitivity and Specificity Sulfadoxine* Uganda |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Drug Combinations; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 58-14-0/Pyrimethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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