| Sympathovagal balance is major determinant of short-term blood pressure variability in healthy subjects. | |
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MedLine Citation:
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PMID: 10199849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short-term blood pressure variability (BPV) has been suggested to provide important information about cardiovascular regulation. However, the background of BPV, its determinants, and physiological correlates have remained obscure. The aim of this study was to characterize physiological correlates of BPV and to investigate associations between BPV and neural and hormonal regulatory systems at rest in healthy subjects. We studied 117 healthy, normal-weight, nonsmoking male and female subjects aged 23-77 yr. Spectral analysis of BPV and heart rate variability (HRV) was performed from 5-min blood pressure (Finapres) and electrocardiogram recordings during controlled breathing. Baroreflex sensitivity (BRS) was measured using the phenylephrine method. In addition, plasma concentrations of norepinephrine, epinephrine, and arginine vasopressin and plasma renin activity were measured. We found that the ratio between the low- and high-frequency components of HRV, an index of cardiac sympathovagal balance, correlated positively with total power and very low- and low-frequency components of systolic and diastolic BPV and inversely with high-frequency components of systolic and diastolic BPV. BRS, predominantly a measure of cardiac vagal regulation, correlated inversely with BPV. Furthermore, age, gender, body mass index, and systolic blood pressure contributed to BPV. Vasoactive hormones were not significant correlates of BPV. We conclude that sympathovagal balance of cardiovascular regulation is the major determinant of BPV. Other factors associated with BPV are age, gender, body mass index, blood pressure, and BRS. |
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Authors:
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T Laitinen; J Hartikainen; L Niskanen; G Geelen; E Länsimies |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 276 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-13 Completed Date: 1999-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1245-52 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, FIN-70211 Kuopio, Finland. Tomi.Laitinen@uku.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology Baroreflex / physiology Blood Pressure / physiology* Body Mass Index Female Heart Rate / physiology Hormones / physiology Humans Male Middle Aged Reference Values Sex Characteristics Sympathetic Nervous System / physiology* Time Factors Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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