Document Detail


Sympathomoderating influence of benazepril in essential hypertension.
MedLine Citation:
PMID:  1316404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In essential hypertension, captopril attenuates forearm vasoconstriction reflexly induced by deactivation of cardiopulmonary and arterial baroreceptors, thus exerting a sympathomoderating effect. We investigated whether this is a common effect of angiotensin converting enzyme (ACE) inhibitors. METHODS AND DESIGN: Cardiopulmonary and arterial baroreceptors were deactivated by progressively reducing central venous pressure (CVP) through progressively greater lower body negative pressures in eight untreated mild essential hypertensives on a moderately low-sodium diet (50 mmol/l per day). This deactivation was performed after oral administration of the non-sulphidrylic ACE inhibitor benazepril (10 mg) and placebo according to a double-blind randomized crossover experimental design. RESULTS: After placebo, the reduction in CVP increased forearm vascular resistance (FVR; mean arterial pressure: plethysmographic forearm blood flow ratio). After benazepril, baseline blood pressure (beat-to-beat finger pressure) and FVR were significantly reduced whilst plasma angiotensin II was suppressed and PRA increased (both measured by radioimmunoassay). The FVR increases induced by progressive CVP reduction were less than after placebo administration, and the overall difference was statistically significant. Benazepril did not affect the reflex FVR reduction observed by increasing CVP through leg raising, nor the reflex changes in plasma norepinephrine measured by high-performance liquid chromatography accompanying the changes in FVR. CONCLUSIONS: Benazepril attenuates sympathetic vasoconstriction as does captopril. This effect (which is mainly operative during an increased sympathetic drive and exerted through a reduction of adrenoceptor responsiveness) is thus likely to be a class- rather than a compound-related feature.
Authors:
C Giannattasio; B M Cattaneo; S Omboni; G Seravalle; G Bolla; L Turolo; A Morganti; G Grassi; A Zanchetti; G Mancia
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  10     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-12     Completed Date:  1992-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  373-8     Citation Subset:  IM; S    
Affiliation:
Cattedra di Medicina Interna, Università di Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Benzazepines / therapeutic use*
Diet, Sodium-Restricted
Double-Blind Method
Female
Humans
Hypertension / drug therapy*
Lower Body Negative Pressure
Male
Middle Aged
Norepinephrine / blood
Pressoreceptors / drug effects
Renin-Angiotensin System / drug effects
Sympathetic Nervous System / drug effects*
Vascular Resistance / drug effects
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 51-41-2/Norepinephrine; 86541-75-5/benazepril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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