Document Detail


Sympatholytic effect of captopril in regression of cardiovascular remodeling in spontaneously hypertensive rats.
MedLine Citation:
PMID:  8010104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-eight spontaneously hypertensive rats (SHR) at 12 wk of age were divided into 3 groups: A) captopril (Cap) 20 mg.kg-1.d-1; B) clonidine (Clo) 30 micrograms.kg-1.d-1; C) Clo 30 micrograms.kg-1.d-1 + Cap 20 mg.kg-1.d-1 orally for 24 wk. Concomitant administration of Cap and Clo did not result in more lowering of the systolic blood pressure (SBP) than that by Cap alone. Regression of left ventricular hypertrophy (LVH) were remarkable in Groups A and C, but not to the extent in that of WKY. No significant difference between these two groups was found. Cap alone resulted in a greater decrease of myocardial norepinephrine (NE) than that of Groups B and C. The wall/lumen ratio and the number of smooth muscle cell (SMC) layers of renal artery decreased in Groups A and C, but little difference was found between them. It seemed that combined blockade of renin-angiotensin-aldosterone (RAA) system and sympathetic nervous system (SNS) did not produce more significant BP reduction and reversal of cardiovascular remodeling than Cap alone did. The sympathetic inhibitory effect of angiotensin converting enzyme inhibitor (ACEI) was not enhanced by sympatholytic treatment.
Authors:
L D Xie; D G Chen; S Zhang; H J Wang; H J Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  15     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Affiliation:
Hypertension Division, First Affiliated Hospital, Fujian Medical College, Fuzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Captopril / pharmacology*
Clonidine / pharmacology
Hypertension / physiopathology*
Hypertrophy, Left Ventricular / drug therapy,  pathology
Myocardium / metabolism
Norepinephrine / metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Renin-Angiotensin System / physiology
Sympathetic Nervous System / physiology
Chemical
Reg. No./Substance:
4205-90-7/Clonidine; 51-41-2/Norepinephrine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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