Document Detail


Sympathoadrenal system activity at birth: integration of postnatal adaptation.
MedLine Citation:
PMID:  3293227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article we have reviewed available information characterizing an increase in SAS activity at birth, in the so-called "catecholamine surge." Also, we have described the sources of circulating CA in the sheep fetus at birth and reviewed recent data on the significance of the CA surge at birth with regard to vital events of postnatal metabolic and cardiovascular adaptations. The results available to date suggest a unique, early neonatal dependence on circulating catecholamines for maintenance of physiologic homeostasis. The duration of this dependence and the ability of newborn animals or humans to sustain such high circulating catecholamine levels is not known. Further studies will clarify the relative importance of circulating and neuronally released CA in these adaptive events in various organ systems and test the applicability of a wide variety of adrenergic agents for therapeutic intervention.
Authors:
J F Padbury; A M Martinez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  12     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-08-18     Completed Date:  1988-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90509.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Adrenal Glands / physiology*
Animals
Animals, Newborn / physiology
Blood Pressure
Catecholamines / metabolism*
Female
Homeostasis
Humans
Infant, Newborn / physiology*
Sheep
Sympathetic Nervous System / physiology*
Vascular Resistance
Grant Support
ID/Acronym/Agency:
HD 18014/HD/NICHD NIH HHS; HD 22003/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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