Document Detail


Sympatho-endocrine and metabolic responses to exercise under post-ganglionic blockade in rats.
MedLine Citation:
PMID:  2904398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to further document the role of locally released norepinephrine (NE) in the control of metabolic and endocrine responses to exercise in rats. Post-ganglionic blockade with bretylium (20 mg.kg-1, i.v.) reduced NE release from sympathetic nerve endings and triggered a compensatory increase in epinephrine (E) release from the adrenal medulla, as reflected by plasma NE and E concentrations at rest and exercise (E/NE ratio = 2.92 +/- 0.53 and 2.48 +/- 0.51 vs 0.62 +/- 0.15 and 1.48 +/- 0.18 in control rats; mean +/- SE). Following bretylium administration a reduction in running time to exhaustion (28 m.min-1, 8% slope: 33 +/- 2 min vs 74 +/- 10 min) was associated with 1) a faster decrease in blood glucose concentration (3.58 +/- 0.80 mM vs 8.09 +/- 0.38 mM in control rats exercised for 33 min); and 2) an increased glycogen store utilization in fast-twitch muscles (superficial vastus lateralis and gastrocnemius lateralis). Glycogen utilization was not modified in soleus muscle and in the liver. Taken together these results suggest that post-ganglionic blockade increased carbohydrate store and peripheral blood glucose utilization. This could reflect an impairment in fat mobilization and utilization which might be secondary to a reduction of NE release in the adipose tissue and/or in the endocrine pancreas.
Authors:
F Trudeau; F Péronnet; L Béliveau; G Brisson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  20     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-01-13     Completed Date:  1989-01-13     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  546-50     Citation Subset:  IM    
Affiliation:
Département d'éducation physique, Université de Montréal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bretylium Compounds / pharmacology*
Bretylium Tosylate / pharmacology*
Epinephrine / blood
Ganglionic Blockers*
Glucagon / blood
Insulin / blood
Male
Norepinephrine / blood,  physiology
Physical Exertion*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Bretylium Compounds; 0/Ganglionic Blockers; 11061-68-0/Insulin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 61-75-6/Bretylium Tosylate; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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