Document Detail


Sympathetic skin response in patients with multiple sclerosis compared with patients with spinal cord transection and normal controls.
MedLine Citation:
PMID:  2065256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 28 patients with definite multiple sclerosis (MS) and 21 patients with a functionally complete transection of the spinal cord sympathetic skin responses (SSR) from both the palms and soles were studied. In the patients with a complete transection at T3 or 4, SSRs were impaired in the palms as well as the soles, and most patients with a transection at T11 or T12 had normal SSRs in the soles. These findings indicate that the central pathway mediating the SSR descends to the upper thoracic cord where connections are made with the sympathetic distribution to the palms, and then to the lower thoracic cord to reach the sympathetic outflow to the soles. This is compatible with the anatomical knowledge of the sympathetic system. Of the MS patients, 75% had abnormal SSR results. The SSR for the soles was more sensitive than that for the palms. The incidence of SSR abnormality was as high as those of somatosensory evoked potential (SEP) (79%) and visual evoked potential (VEP) (75%) abnormalities. Of the patients with normal SEPs 14% had impaired SSRs and 21% had abnormal SSR with normal VEPs. When the results of these 3 tests were combined, the abnormality increased to 100%. From our study, the SSR probably reflects not only postganglionic sympathetic activity but also preganglionic function. The SSR is therefore useful in evaluating myelopathy, providing information different from that given by assessment of the somatic nervous system. Since the SSR detected a few MS lesions which were not demonstrated by other evoked potentials, it is potentially a new tool for the detection of MS lesions in addition to conventional evoked potential studies.
Authors:
T Yokota; T Matsunaga; R Okiyama; K Hirose; H Tanabe; T Furukawa; H Tsukagoshi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  114 ( Pt 3)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-08-15     Completed Date:  1991-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1381-94     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Electric Stimulation
Evoked Potentials, Somatosensory
Evoked Potentials, Visual
Female
Foot
Galvanic Skin Response*
Hand
Humans
Male
Median Nerve / physiopathology
Multiple Sclerosis / physiopathology*
Reference Values
Spinal Cord Injuries / physiopathology*
Sympathetic Nervous System / physiology,  physiopathology*
Tibial Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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