Document Detail

Sympathetic skin response in migraineurs and patients with medication overuse headache.
MedLine Citation:
PMID:  15109353     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Autonomic dysfunction has been reported in patients with migraine, and it may play a role in promoting attacks. OBJECTIVE: To investigate changes in the autonomic function of migraineurs and patients with medication overuse headache via sympathetic skin response, and to determine whether psychiatric comorbidity is related to any changes recorded. METHODS: A consecutive series of patients with migraine (n = 45) and medication overuse headache (n = 53) were studied. Patients with other chronic diseases requiring medication were excluded. Sympathetic skin response latencies and amplitudes from the patients with headache (N = 98) and 40 healthy controls were compared statistically. RESULTS: Sympathetic skin response latencies in patients with medication overuse headache and in migraineurs were significantly longer than in controls. To analyze the effect of psychiatric comorbidity, patients with medication overuse headache and migraineurs were each divided into 2 groups: those with psychiatric comorbidity and those without comorbidity. When the sympathetic skin response results of these 4 groups were compared with controls, the only statistically significant difference was between the sympathetic skin response latencies of controls and the latencies of patients with psychiatric comorbidity. We could not find any difference between the results from patients without psychiatric comorbidity and those of controls. CONCLUSION: Psychiatric disease may affect the results of autonomic function testing in migraineurs and patients with medication overuse headache. Consideration should be given to excluding patients with psychiatric comorbidity from studies investigating autonomic dysfunction in patients with headache.
Huseyin T Atasoy; Nuray Atasoy; Aysun E Unal; Murat Sumer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Headache     Volume:  44     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-08-12     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Zonguldak Karaelmas University, Faculty of Medicine, Department of Neurology, Turkey.
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MeSH Terms
Headache Disorders / chemically induced*,  physiopathology*
Mental Disorders / physiopathology*
Migraine Disorders / physiopathology*
Skin / innervation*
Sympathetic Nervous System / physiopathology*

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