Document Detail


Sympathetic responses during saline infusion into the veins of an occluded limb.
MedLine Citation:
PMID:  19470776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animal studies have shown that the increased intravenous pressure stimulates the group III and IV muscle afferent fibres, and in turn induce cardiovascular responses. However, this pathway of autonomic regulation has not been examined in humans. The aim of this study was to examine the hypothesis that infusion of saline into the venous circulation of an arterially occluded vascular bed evokes sympathetic activation in healthy individuals. Blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) responses were assessed in 19 young healthy subjects during local infusion of 40 ml saline into a forearm vein in the circulatory arrested condition. From baseline (11.8 +/- 1.2 bursts min(-1)), MSNA increased significantly during the saline infusion (22.5 +/- 2.6 bursts min(-1), P < 0.001). Blood pressure also increased significantly during the saline infusion. Three control trials were performed during separate visits. The results from the control trial show that the observed MSNA and blood pressure responses were not due to muscle ischaemia. The present data show that saline infusion into the venous circulation of an arterially occluded vascular bed induces sympathetic activation and an increase in blood pressure. We speculate that the infusion under such conditions stimulates the afferent endings near the vessels, and evokes the sympathetic activation.
Authors:
Jian Cui; Patrick McQuillan; Raman Moradkhan; Charles Pagana; Lawrence I Sinoway
Related Documents :
19907006 - Il-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor ref...
10940456 - Acute responses of renal nerve activity to microgravity induced by free drop in anesthe...
9747906 - High blood pressure management: potential benefits of i1 agents.
4042286 - The renal sympathetic baroreflex in the rabbit. arterial and cardiac baroreceptor influ...
9120776 - Portal hypotensive effects of tetrandrine and verapamil in portal hypertensive rats.
8652326 - Carbon dioxide output in laparoscopic cholecystectomy.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-26
Journal Detail:
Title:  The Journal of physiology     Volume:  587     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-10-15     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3619-28     Citation Subset:  IM    
Affiliation:
Penn State Heart & Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Arm / blood supply*,  innervation,  physiology
Blood Pressure / drug effects,  physiology*
Female
Heart Rate / drug effects,  physiology*
Humans
Infusions, Intravenous
Male
Muscle, Skeletal / drug effects,  innervation,  physiology*
Sodium Chloride / administration & dosage*
Sympathetic Nervous System / drug effects,  physiology*
Vasoconstriction
Veins / drug effects,  physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR010732/RR/NCRR NIH HHS; P01 HL077670/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by Galph...
Next Document:  Citrobacter rodentium colitis evokes post-infectious hyperexcitability of mouse nociceptive colonic ...