Document Detail

Sympathetic response to chemostimulation in conscious rats exposed to chronic intermittent hypoxia.
MedLine Citation:
PMID:  19429526     Owner:  NLM     Status:  MEDLINE    
Exposure to cyclic intermittent hypoxia (CIH) is associated with elevated arterial pressure and sustained sympathoexcitation, but the causes of the augmented sympathetic activity remain poorly understood. We recorded arterial pressure, heart rate, and renal sympathetic nerve (RSN) activity in conscious rats previously exposed to either CIH or Sham for 3 weeks during acute exposure to hypoxia (15% and 10% O(2)) or hypercapnia (7% CO(2)). Hemodynamic responses to both hypercapnia and hypoxia were similar between CIH-exposed and Sham-exposed rats, although the pattern of response was different for hypoxia (tachycardia with no change in arterial pressure) and hypercapnia (bradycardia and increased arterial pressure). RSN responses as a percent of the baseline were, however, significantly greater in CIH-exposed animals (CIH-exposed: 15% O(2) - 123.4+/-0.06%; 10% O(2) - 136.7+/-0.12%; 7% CO(2) - 138.3+/-0.18%; Sham-exposed: 15% O(2) - 106.6+/-0.03%; 10% O(2) - 107.6+/-0.01%; 7% CO(2) - 103.0+/-0.14% P<0.01 for all conditions). These data indicate that in conscious rats exposure to CIH enhances sympathetic responses to both hypoxia and hypercapnia.
Jianhua Huang; Sara Lusina; Tian Xie; Ensheng Ji; Shuanglin Xiang; Yuzhen Liu; J Woodrow Weiss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-03
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  166     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Pulmonary and Sleep Research Laboratory, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, GZ 405, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
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MeSH Terms
Analysis of Variance
Anoxia / pathology*,  physiopathology
Blood Pressure / physiology
Heart Rate / physiology
Hemodynamics / physiology*
Hypercapnia / pathology*,  physiopathology*
Kidney / innervation
Rats, Sprague-Dawley
Stimulation, Chemical
Sympathetic Nervous System / drug effects,  physiopathology*
Grant Support

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