| Sympathetic response to chemostimulation in conscious rats exposed to chronic intermittent hypoxia. | |
| | |
MedLine Citation:
|
PMID: 19429526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exposure to cyclic intermittent hypoxia (CIH) is associated with elevated arterial pressure and sustained sympathoexcitation, but the causes of the augmented sympathetic activity remain poorly understood. We recorded arterial pressure, heart rate, and renal sympathetic nerve (RSN) activity in conscious rats previously exposed to either CIH or Sham for 3 weeks during acute exposure to hypoxia (15% and 10% O(2)) or hypercapnia (7% CO(2)). Hemodynamic responses to both hypercapnia and hypoxia were similar between CIH-exposed and Sham-exposed rats, although the pattern of response was different for hypoxia (tachycardia with no change in arterial pressure) and hypercapnia (bradycardia and increased arterial pressure). RSN responses as a percent of the baseline were, however, significantly greater in CIH-exposed animals (CIH-exposed: 15% O(2) - 123.4+/-0.06%; 10% O(2) - 136.7+/-0.12%; 7% CO(2) - 138.3+/-0.18%; Sham-exposed: 15% O(2) - 106.6+/-0.03%; 10% O(2) - 107.6+/-0.01%; 7% CO(2) - 103.0+/-0.14% P<0.01 for all conditions). These data indicate that in conscious rats exposure to CIH enhances sympathetic responses to both hypoxia and hypercapnia. |
| | |
Authors:
|
Jianhua Huang; Sara Lusina; Tian Xie; Ensheng Ji; Shuanglin Xiang; Yuzhen Liu; J Woodrow Weiss |
Related Documents
:
|
8901316 - Central alveolar hypoventilation (ondine's curse) treated with negative pressure ventil... 8973756 - Role of the autonomic nervous system in the acute blood pressure elevation during repet... 8954296 - Human erythropoietin response to hypocapnic hypoxia, normocapnic hypoxia, and hypocapni... 8282626 - Tracheobronchial dilation during isocapnic hypoxia in conscious humans. 17330056 - Beta-blockers do not impair the cardiovascular benefits of endurance training in hypert... 1155476 - Negative influences of ascites on the cardiac function of cirrhotic patients. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-03 |
Journal Detail:
|
Title: Respiratory physiology & neurobiology Volume: 166 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-05-11 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 102-6 Citation Subset: IM |
Affiliation:
|
Pulmonary and Sleep Research Laboratory, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, GZ 405, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Anoxia / pathology*, physiopathology Blood Pressure / physiology Conscience* Heart Rate / physiology Hemodynamics / physiology* Hypercapnia / pathology*, physiopathology* Kidney / innervation Male Rats Rats, Sprague-Dawley Stimulation, Chemical Sympathetic Nervous System / drug effects, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL075184/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharyngeal muscle contraction modifies peri-pharyngeal tissue pressure in rabbits.
Next Document: Membrane-associated carbonic anhydrase in the respiratory system of the Pacific hagfish (Eptatretus ...