Document Detail

Sympathetic and respiratory responses to hypoxia in essential hypertension.
MedLine Citation:
PMID:  10225480     Owner:  NLM     Status:  MEDLINE    
An increased sympathetic nervous response to hypoxia and reduced beta-adrenergic receptor function have been reported in hypertension. This study examines the relationship between hypoxia and beta-adrenergic receptor function in sixteen normotensive and eight hypertensive subjects. We measured the average arterial oxygen saturation and the end tidal carbon dioxide partial pressure in hypertensive and normotensive groups under normoxia and mild isocapnic hypoxia (15% O2, 85% N2). The ratio of isoproterenol-stimulated cAMP to basal cAMP on lymphocytes was measured in the two groups under normoxia. We also measured plasma norepinephrine levels and calculated the "Chronotropic 25 Dose" of isoproterenol in the two groups under normoxia and hypoxia. Hypertensives had higher plasma norepinephrine levels for either breathing condition (F=7.16, p=0.015). Under hypoxia, hypertensives showed a significant decrease in the average arterial oxygen saturation (F=4.92, p=0.038) and higher "Chronotropic 25 Dose" implying decreased beta-adrenergic receptor sensitivity (F=6.30, p=0.011). These results suggest that hypertensives have a diminished ventilatory response and impaired beta-adrenergic response under hypoxia.
B H Yu; P J Mills; M G Ziegler; J E Dimsdale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  21     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-06     Completed Date:  1999-07-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-62     Citation Subset:  IM    
Department of Psychiatry, Samsung Medical Center, Sung Kyun Kwan University, College of Medicine, Seoul, Korea.
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage
Anoxia / complications,  physiopathology*
Cyclic AMP / metabolism
Hypertension / complications,  physiopathology*
Isoproterenol / administration & dosage
Lymphocytes / drug effects,  metabolism
Middle Aged
Norepinephrine / blood
Receptors, Adrenergic, beta / physiology
Respiratory System / drug effects,  physiopathology*
Sympathetic Nervous System / drug effects,  physiopathology*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

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