| Sympathetic, parasympathetic and enteric regulation of the gastrointestinal vasculature in rainbow trout (Oncorhynchus mykiss) under normal and postprandial conditions. | |
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MedLine Citation:
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PMID: 20802112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The control of the gastrointestinal hyperemia that occurs after feeding in most animals is of fundamental importance for the subsequent absorption, metabolism and redistribution of nutrients. Yet, in fish, it has received little attention and the nature of it is far from clear. We sought to investigate the importance of extrinsic and intrinsic innervation of the gastrointestinal tract in the regulation of gastrointestinal blood flow in rainbow trout (Oncorhynchus mykiss). The contribution of the extrinsic innervation, i.e. by the sympathetic and the parasympathetic nervous system, was examined by comparing the response to the injection of a predigested nutrient diet into the proximal intestine of untreated fish with the response in fish in which the splanchnic and vagal innervation of the gut had been removed. We also injected the predigested nutrient diet into anaesthetized fish treated with tetrodotoxin that would block the intrinsic innervation of the gut (i.e. enteric nervous system). Our results confirm the notion that the sympathetic portion of the extrinsic innervation maintains the basal vascular tone, but neither the splanchnic nor the vagal innervation is fundamental to the postprandial hyperemia. However, the tetrodotoxin treatment completely abolished the postprandial hyperemia, indicating the importance of the enteric nervous system. In conclusion, it seems as though the enteric nervous system is essential to the regulation of the postprandial hyperemia, and that the extrinsic innervation is involved mainly in the regulation of gastrointestinal blood flow under normal conditions and in response to central coordination with other organs. |
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Authors:
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Henrik Seth; Michael Axelsson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of experimental biology Volume: 213 ISSN: 1477-9145 ISO Abbreviation: J. Exp. Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243705 Medline TA: J Exp Biol Country: England |
Other Details:
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Languages: eng Pagination: 3118-26 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of Gothenburg, S-405 30 Gothenburg, Sweden. henrik.seth@zool.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Enteric Nervous System / drug effects, physiology* Gastrointestinal Tract* / blood supply, innervation Heart Rate / physiology Hemodynamics Hyperemia Oncorhynchus mykiss / anatomy & histology*, physiology* Parasympathetic Nervous System / physiology* Postprandial Period / physiology* Regional Blood Flow / physiology Sodium Channel Blockers / pharmacology Sympathetic Nervous System / physiology* Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Sodium Channel Blockers; 4368-28-9/Tetrodotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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