Document Detail

Sympathetic overactivity in ischaemic heart disease.
MedLine Citation:
PMID:  15030311     Owner:  NLM     Status:  MEDLINE    
The efficacy of pharmacological beta-blockade in decreasing cardiac death in patients after myocardial infarction suggests the existence of sympathetic overactivity and indicates the importance of assessing its magnitude. The paper by Graham and co-workers in this issue of Clinical Science has attempted to address this issue by measuring muscle sympathetic nerve activity (MSNA) in various groups of patients and control subjects. It was found that, after myocardial infarction, there was sympathetic overactivity, which was more marked and more long-lasting than after unstable angina, whereas, in the presence of simple coronary artery disease, sympathetic activity did not differ from that in control subjects. Clear signs of sympathetic overactivity lasting for months after an acute myocardial infarction have already been reported using quite different methodology, i.e. spectral analysis of heart period and systolic arterial pressure variability. The soundest hypothesis to explain such a sympathetic overactivity appears to be based on the well-demonstrated finding that the ischaemic heart is a powerful site of origin of both excitatory and/or inhibitory reflexes, which may be of paramount clinical importance.
Alberto Malliani; Nicola Montano
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  106     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-8     Citation Subset:  IM    
Dipartimento di Scienze Cliniche Luigi Sacco, Università degli Studi di Milano, Via GB Grassi, 74-20157 Milano, Italy.
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MeSH Terms
Acute Disease
Angina, Unstable / physiopathology
Coronary Artery Disease / physiopathology
Heart Rate
Muscle, Skeletal / physiopathology
Myocardial Infarction / physiopathology
Myocardial Ischemia / physiopathology*
Sympathetic Nervous System / physiopathology*
Comment On:
Clin Sci (Lond). 2004 Jun;106(6):605-11   [PMID:  14759219 ]

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