| Sympathetic neuropathy in diabetes mellitus patients does not elicit Charcot osteoarthropathy. | |
| | |
MedLine Citation:
|
PMID: 21813289 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: The aim of the study was to determine the degree of neuropathy (autonomic and somatic) in patients with diabetes mellitus with or without Charcot osteoarthropathy (CA). METHODS: Forty-nine patients with diabetes mellitus type 1 or 2 were investigated. The patient population of interest was the patients with acute Charcot foot (n=17) or chronic Charcot foot (n=7). The inclusion criterion for an acute Charcot foot was a temperature difference of more than 2° between the two feet, oedema of the affected foot, typical hotspots in a bone scintigram and a typical clinical course. In addition, patients with first toe amputation (n=5), a high-risk group for development of CA, and two control groups consisting of diabetes patients with (n=9) or without somatic neuropathy (n=11) were investigated. Regional blood flow in the feet was measured by venous occlusion plethysmography. Quantitation of somatic neuropathy was done by the Neuropathy Disability Score and modified Neuropathy Symptom Score. Quantitation of autonomic neuropathy was done by measurements of local venoarteriolar sympathetic axon reflex in the feet and of heart rate variability during deep breathing and orthostatic challenge. RESULTS: The patients with acute Charcot foot and first toe amputation had an increased blood flow in the affected foot and weakened but not absent venoarteriolar sympathetic axon reflex. In the other patient groups, a normal venoarteriolar sympathetic axon reflex in the feet was found. CONCLUSIONS: Peripheral sympathetic neuropathy is not likely to be the pathophysiologic mechanism behind the hyperemia in the foot during an acute attack of CA. The hyperemia is more likely secondary to local inflammatory events. |
| | |
Authors:
|
Tomas M Christensen; Lene Simonsen; Per E Holstein; Ole L Svendsen; Jens Bülow |
Related Documents
:
|
2266199 - Effect of plane of nutrition on insulin sensitivity during lactation in the ewe. 8178989 - Disposition of a mixed meal by the conscious dog. 6493499 - Friedreich's ataxia: intravenous pyruvate load to demonstrate a defect in pyruvate meta... 10356109 - Primary hypoxic tolerance and chemical preconditioning during estrus cycle in mice. 16575559 - Insights into the role of anaplerosis in insulin secretion: a 13c nmr study. 396109 - Plasma levels of glucose and lactate after intravenous glipizide administration in some... 9222639 - Advanced glycation end products and their receptors co-localise in rat organs susceptib... 7733029 - Whole-body protein turnover in response to hyperinsulinemia in humans postabsorptively ... 1425099 - C-peptide response to meal challenge in nondiabetic and diabetic adults living in waden... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-1 |
Journal Detail:
|
Title: Journal of diabetes and its complications Volume: - ISSN: 1873-460X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department Endocrinology and Gastroenterology I, Bispebjerg University Hospital, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sad people are more accurate at face recognition than happy people.
Next Document: Increased IL-6 levels are not related to NF-?B or HIF-1? transcription factors activity in the vitre...