| Sympathetic neural mechanisms in human hypertension. | |
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MedLine Citation:
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PMID: 18765097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compared with substantial clinical research on the renin-angiotensin-aldosterone system (RAAS), much less is known about the importance of the sympathetic nervous system as a therapeutic target to slow the initiation and progression of human hypertension. Using microelectrode recordings of sympathetic activity and radiotracer measurements of regional norepinephrine spillover in hypertensive patients, recent research has advanced several provocative findings with novel--but still largely potential--therapeutic implications for clinical hypertension. These include a stronger scientific rationale for using 1) combined alpha/beta-blockers in the early phases of primary hypertension and obesity-related hypertension; 2) RAAS blockers as central sympatholytics in hypertension associated with chronic kidney disease; and 3) a higher dialysis dose--either nocturnal or short daily hemodialysis--to reduce uremic stimulation of a blood pressure--raising reflex arising in the failing kidneys. New outcomes trials are needed if we are to translate this largely theoretical body of research into clinical practice. |
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Authors:
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Ronald G Victor; Moiz M Shafiq |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 10 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 241-7 Citation Subset: IM |
Affiliation:
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Internal Medicine, Hypertension Division, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. ronald.victor@utsouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Disease Progression Humans Hypertension / diagnosis, etiology, metabolism, physiopathology* Kidney Failure, Chronic / prevention & control Neurotransmitter Agents / metabolism* Obesity / complications Renin-Angiotensin System / drug effects Sympathetic Nervous System / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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