Document Detail


Sympathetic nervous system response to orthostatic stress in female patients with rheumatoid arthritis.
MedLine Citation:
PMID:  19120157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sympathoneural and adrenomedullary impairments have been suggested in patients with rheumatoid arthritis (RA). In the present study, sympathoneural and adrenomedullary responses to orthostasis were evaluated in eight female RA patients and in eight matched healthy controls. The testing consisted of sequence of stabilization period in supine position, legs-up position, orthostasis, and supine position. In each body position, blood samples were drawn and ECG was recorded. Plasma levels of epinephrine (EPI), norepinephrine (NE) and neuropeptide Y (NPY) were measured and sympathoneural activity was evaluated by analysis of heart rate variability (HRV). Higher baseline NE levels were found in RA patients (P= 0.034), without any difference in response to orthostasis between the study groups. Levels of EPI tended to be lower in RA patients in base line (P= 0.053) and in response to orthostasis (P= 0.079). The RA and control groups did not differ in NPY levels or in HRV parameters considered to reflect sympathetic activity. A subtle tendency to decreased adrenomedullary reactivity but no evidence for abnormal sympathetic responses to orthostasis was found in RA females.
Authors:
Miroslav Vlcek; Jozef Rovensky; Pavel Blazicek; Zofia Radikova; Adela Penesova; Jana Kerlik; Richard Kvetnanský; Richard Imrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1148     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-61     Citation Subset:  IM    
Affiliation:
Institute of Experimental Endocrinology, SAS, Bratislava, Slovakia. miroslav.vlcek@savba.sk
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / metabolism
Adult
Arthritis, Rheumatoid / blood*
Dizziness*
Electrocardiography
Epinephrine / blood
Female
Heart Rate / physiology
Humans
Neuropeptide Y / blood
Norepinephrine / blood
Stress, Physiological*
Supine Position
Sympathetic Nervous System / physiology*
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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