| Sympathetic nervous system in high sodium one-kidney, figure-8 renal hypertension. | |
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MedLine Citation:
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PMID: 1618557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of the sympathetic nervous system and vasopressin to the maintenance of arterial pressure was investigated in high sodium-fed rats 4 weeks after the induction of one-kidney, figure-8 renal wrap hypertension. Arterial pressure was significantly greater in renal-wrapped rats than in sham-operated animals. The contribution of the sympathetic nervous system was assessed functionally by measuring the arterial pressure response to ganglionic blockade and estimating the apparent rate of release of norepinephrine. The contribution of vasopressin was assessed by administration of the vascular antagonist d(CH2)5Tyr(Me)-AVP. Whole-animal vascular responsiveness and cardiac baroreceptor reflex sensitivity were determined by graded intravenous bolus injections of angiotensin II, vasopressin, and phenylephrine. Hypertensive rats demonstrated an exaggerated reduction in arterial pressure to autonomic blockade before and after blockade of vascular vasopressin receptors. There was a significant 27% increase in the apparent rate of release of norepinephrine into the plasma. Administration of d(CH2)5Tyr(Me)-AVP did not affect arterial pressure when given alone. However, after ganglionic blockade, inhibition of the vasopressin system elicited similar falls in blood pressure in both normotensive and hypertensive rats. Arterial pressure dose-response effects of phenylephrine, angiotensin II, and vasopressin were similar between renal-wrapped and sham-operated animals; however, cardiac baroreceptor reflex sensitivity was suppressed in the hypertensive rats. These studies indicate that the maintenance of arterial pressure in chronic, high sodium renal-wrap hypertension is associated with an augmented sympathetic nervous system function. |
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Authors:
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C Hinojosa-Laborde; P Guerra; J R Haywood |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 20 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-07-31 Completed Date: 1992-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 96-102 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / pharmacology Blood Pressure / drug effects Diet Hypertension, Renal / physiopathology* Male Norepinephrine / metabolism Pressoreceptors / drug effects Rats Rats, Inbred Strains Reflex / drug effects Sodium / administration & dosage*, pharmacology Vasoconstrictor Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-32977/HL/NHLBI NIH HHS; HL-36080/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 113-79-1/Arginine Vasopressin; 51-41-2/Norepinephrine; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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