Document Detail


Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity.
MedLine Citation:
PMID:  20724568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The airways contain a dense subepithelial microvascular plexus that is involved in the supply and clearance of substances to and from the airway wall. We set out to test the hypothesis that airway smooth muscle reactivity to bronchoconstricting agents may be dependent on airway mucosal blood flow. Immunohistochemical staining identified vasoconstrictor and vasodilator nerve fibers associated with subepithelial blood vessels in the guinea pig airways. Intravital microscopy of the tracheal mucosal microvasculature in anesthetized guinea pigs revealed that blockade of α-adrenergic receptors increased baseline arteriole diameter by ~40%, whereas the α-adrenergic receptor agonist phenylephrine produced a modest (5%) vasoconstriction in excess of the baseline tone. In subsequent in vivo experiments, tracheal contractions evoked by topically applied histamine were significantly reduced (P < 0.05) and enhanced by α-adrenergic receptor blockade and activation, respectively. α-Adrenergic ligands produced similar significant (P < 0.05) effects on airway smooth muscle contractions evoked by topically administered capsaicin, intravenously administered neurokinin A, inhaled histamine, and topically administered antigen in sensitized animals. These responses were independent of any direct effect of α-adrenergic ligands on the airway smooth muscle tone. The data suggest that changes in blood flow in the vessels supplying the airways regulate the reactivity of the underlying airway smooth muscle to locally released and exogenously administered agents by regulating their clearance. We speculate that changes in mucosal vascular function or changes in neuronal regulation of the airway vasculature may contribute to airways responsiveness in disease.
Authors:
Stuart B Mazzone; Lina H K Lim; Elizabeth M Wagner; Nanako Mori; Brendan J Canning
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-19
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-02-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1292-300     Citation Subset:  IM    
Affiliation:
The University of Queensland, School of Biomedical Sciences, St. Lucia, Queensland, Australia. s.mazzone@uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Administration, Topical
Adrenergic alpha-Agonists / administration & dosage
Adrenergic alpha-Antagonists / administration & dosage
Animals
Bronchoconstriction* / drug effects
Bronchoconstrictor Agents / administration & dosage
Dose-Response Relationship, Drug
Guinea Pigs
Injections, Intravenous
Male
Microcirculation*
Microvessels / innervation*
Muscle, Smooth / drug effects,  physiology*
Neuropeptides / administration & dosage
Regional Blood Flow
Respiratory Mucosa / blood supply*
Sympathetic Nervous System / physiology*
Time Factors
Trachea / blood supply*
Vasoconstriction
Vasodilation
Vasomotor System / physiology
Grant Support
ID/Acronym/Agency:
HL-58525/HL/NHLBI NIH HHS; R01 HL058525/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Bronchoconstrictor Agents; 0/Neuropeptides
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2010 Nov;109(5):1287   [PMID:  20847125 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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