Document Detail


Sympathetic nerve activity and insulin in obese normotensive and hypertensive men.
MedLine Citation:
PMID:  8567052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between resting levels of muscle sympathetic nerve activity (MSA) and blood pressure is a matter of controversy. Body weight has recently been identified as an independent determinant of muscle sympathetic discharge, which may have influenced previous studies focused on MSA and mechanisms of hypertension. In the present study, we measured resting MSA and plasma insulin levels in 18 obese (body mass index, 32 +/- 4 kg/m2) (mean +/- SD), middle-aged (52 +/- 6 years), hypertensive (155 +/- 11/97 +/- 8 mm Hg) subjects and 16 age- and body mass index-matched normotensive control subjects. In the postabsorptive state, resting MSA was similar in the hypertensive and normotensive groups (43 +/- 4 versus 39 +/- 3 bursts per minute, 69 +/- 5 versus 64 +/- 5 bursts per 100 heart beats, P = NS) (mean +/- SEM) and did not correlate with either systolic or diastolic blood pressure. Weak but significant positive correlations were found between resting MSA and both fasting insulin levels (P < .05) and body mass index (P = .05) in hypertensive but not normotensive subjects. There was a strong positive correlation between fasting insulin and body mass index in both normotensive subjects and the entire study group (P < .005). Fasting insulin and body mass index correlated with diastolic blood pressure (P < .05) in the entire study group. In conclusion, a relationship between fasting insulin, body mass index, and blood pressure was confirmed, whereas only a weak correlation was found between MSA and fasting insulin in hypertensive but not normotensive subjects. The fact that MSA was similar in the two groups argues strongly against augmented MSA being important for the maintenance of hypertension, at least in middle-aged, obese men.
Authors:
S Gudbjörnsdóttir; P Lönnroth; Y B Sverrisdóttir; B G Wallin; M Elam
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  27     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-80     Citation Subset:  IM    
Affiliation:
Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Blood Pressure*
Body Mass Index
Diastole
Humans
Hypertension / blood,  complications,  physiopathology*
Insulin / blood*
Male
Middle Aged
Muscle, Skeletal / innervation*
Obesity / blood,  complications,  physiopathology*
Regression Analysis
Sympathetic Nervous System / physiopathology*
Systole
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin
Comments/Corrections
Erratum In:
Hypertension 1996 Apr;27(4):1030

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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