Document Detail

Sympathetic nerve activity after thoracoscopic cardiac resynchronization therapy in congestive heart failure.
MedLine Citation:
PMID:  16198249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sympathetic benefits of thoracoscopic cardiac resynchronization therapy (TCRT) in congestive heart failure (CHF) are unknown. We determined cardiac hemodynamics, functional status, and muscle sympathetic nerve activity (MSNA) in a group of TCRT patients. We aimed to compare these patients with CHF patients with cardiac asynchrony (ASY) to substantiate the beneficial effects of TCRT. METHODS AND RESULTS: Eleven patients resynchronized by TCRT 6 +/- 1 months before study inclusion (SYN) and 10 matched ASY patients underwent blood pressure, heart rate, and MSNA recordings. All underwent functional status, cardiac index, and left ventricular ejection fraction (LVEF) assessments. SYN patients had shorter QRS duration and interventricular mechanical delays, longer 6 minute walking distance and lower New York Heart Association class (all P < .05) than ASY patients. MSNA of 56 +/- 2 bursts/min in ASY patients was higher than in SYN patients (48 +/- 3 bursts/min, P < .05). Cardiac index was higher in SYN patients than in ASY patients (2.8 +/- 0.2 versus 1.9 +/- 0.2 L.min.m2, P < .05, respectively). MSNA was highest in the patients with the lowest LVEF (r = -0.49, P < .05), cardiac index (r = -0.48, P < .05) and 6-minute walking distance (r = -0.50, P < .05). CONCLUSION: Lower sympathetic nerve activities in TCRT patients are related to more favorable cardiac indexes and six minute walking distances suggesting a sympathetic, hemodynamic, and functional improvement by TCRT.
Boutaïna Najem; Nicolas Preumont; Philippe Unger; Jean-Luc Jansens; Anne Houssière; Agnieszka Ciarka; Eric Stoupel; Jean-Paul Degaute; Philippe van de Borne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  11     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-02-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Department of Cardiology, Erasme Hospital, Brussels, Belgium.
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MeSH Terms
Blood Pressure / physiology
Exercise Tolerance / physiology
Heart Conduction System / physiopathology,  ultrasonography
Heart Failure / physiopathology,  therapy*,  ultrasonography
Heart Rate / physiology
Heart Ventricles / physiopathology,  ultrasonography
Middle Aged
Pacemaker, Artificial*
Stroke Volume / physiology
Sympathetic Nervous System / physiopathology*,  ultrasonography
Treatment Outcome
Walking / physiology

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