Document Detail


THE SYMPATHETIC MECHANISM IN THE ISOLATED PULMONARY ARTERY OF THE RABBIT.
MedLine Citation:
PMID:  14126048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nature of postganglionic sympathetic nervous transmission to vascular muscle in vitro was studied using the recurrent cardiac nerve-pulmonary artery preparation of the rabbit. Experiments, similar to those which in other tissues have provided evidence to support a role for acetylcholine at the sympathetic postganglionic nerve-effector cell junction, were carried out. The contractile response of the isolated artery to acetylcholine was blocked completely by atropine. High concentrations of acetylcholine and of hemicholinium had no effect on the contractile response to sympathetic nerve stimulation. Physostigmine, atropine and hemicholinium were without influence on the relationship between nerve stimulus frequency and response. Yohimbine, bretylium and reserpine blocked completely the response to nerve stimulation but did not affect that to applied acetylcholine. These results support the view that transmission in this preparation at the sympathetic postganglionic nerve-effector cell junction is mediated by an adrenaline-like transmitter and provide no evidence for the view that acetylcholne is involved at this site.
Authors:
J A BEVAN; C SU
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  22     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1964 Feb 
Date Detail:
Created Date:  1964-07-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  176-82     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine*
Atropine*
Biphenyl Compounds*
Bretylium Compounds*
Choline*
Electric Stimulation*
Ganglionic Blockers*
Pharmacology*
Physostigmine*
Pulmonary Artery*
Rabbits*
Research*
Sympathetic Nervous System*
Yohimbine*
Chemical
Reg. No./Substance:
0/Biphenyl Compounds; 0/Bretylium Compounds; 0/Ganglionic Blockers; 146-48-5/Yohimbine; 51-55-8/Atropine; 51-84-3/Acetylcholine; 57-47-6/Physostigmine; 62-49-7/Choline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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