| Sympathetic influences on the native canine coronary collateral circulation. | |
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MedLine Citation:
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PMID: 7895236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim was to investigate the influence of the sympathetic nervous system on the native collateral circulation in the intact heart. METHODS: Experiments were performed on 10 open chest dogs anaesthetised with alpha chloralose. The left anterior descending coronary artery was cannulated and embolised with 25 microns microspheres. Collateral resistance was determined from measurements of aortic pressure and retrograde flow. Additional haemodynamic measurements included left ventricular pressure and blood flow in the circumflex coronary artery. RESULTS: Coronary embolisation decreased retrograde resistance from 41.5(SEM 6.0) to 20.1(1.9) mm Hg.ml-1.min-1 (P < 0.01). Left stellate stimulation for 60 s (10 Hz) significantly increased circumflex blood flow and decreased circumflex resistance from 2.1(0.3) to 1.6(0.2) mm Hg.ml-1.min-1. Retrograde resistance during sympathetic stimulation decreased from 19.7(1.8) mm Hg.ml-1.min-1 (P < 0.01). Transient occlusion of descending aorta resulted in changes in perfusion pressure and retrograde flow that were similar to those observed during stellate stimulation. Stellate stimulation after beta blockade with timolol (0.1 mg.kg-1) increased circumflex resistance from 1.9(0.2) to 2.3(0.3) mm Hg.ml-1.min-1 (P < 0.01) but did not alter retrograde resistance. CONCLUSIONS: The sympathetic nervous system does not have a direct effect on native coronary collateral vessels. Increased sympathetic input to the heart does not result in a coronary steal phenomenon. The primary determinant of flow and resistance in the native collateral network during sympathetic activation is the arterial perfusion pressure. |
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Authors:
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D E Euler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 29 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-04-21 Completed Date: 1995-04-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: IM |
Affiliation:
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Department of Physiology, Loyola University Medical Center, Maywood, IL 60153. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Collateral Circulation / physiology* Coronary Circulation / physiology* Coronary Disease / physiopathology Dogs Electric Stimulation Electromagnetic Phenomena Embolism Female Male Perfusion Regional Blood Flow / physiology Sympathetic Nervous System / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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