Document Detail

Sympathetic hyperactivity in patients with vasospastic angina--assessment by spectral analysis of heart rate and arterial pressure variabilities.
MedLine Citation:
PMID:  8648879     Owner:  NLM     Status:  MEDLINE    
The autonomic nervous system may play an important role in regulating coronary arterial tone. To evaluate the role of autonomic nervous activity in patients with vasospastic angina (VSA), we studied 10 VSA patients with patent coronary artery (mean; 56 yr, range; 44-66 yr) and 8 normal subjects (mean; 58 yr, range; 35-71 yr). ECG and arterial pressure were continuously recorded for 4 min in a supine position at 7:30 am, 10:30 am, and 4:30 pm. Low-frequency (LF; 0.04-0.15 Hz) and high-frequency (HF; 0.20 Hz) components of the beat-to-beat variabilities of the R-R interval (RRI) and systolic arterial pressure (SAP) were then estimated by autoregressive power spectral analysis. The LF-Normalized Power (LF-NP; [LF Power]/[Total Power]-[Direct Current Power]) of both the RRI and SAP variabilities were greater in VSA patients than in normal subjects (RRI: 0.51 +/- 0.07, 0.51 +/- 0.07, 0.53 +/- 0.06, vs 0.25 +/- 0.04, 0.31 +/- 0.05, 0.31 +/- 0.06, at 7:30 am, 10:30 am, and 4:30 pm respectively: p = 0.010, 0.044, 0.018. SAP: 0.62 +/- 0.06, 0.53 +/- 0.06, 0.57 +/- 0.06 vs 0.37 +/- 0.04, 0.30 +/- 0.06, 0.26 +/- 0.07, respectively: p = 0.006, 0.017, 0.003.). The LF-power of SAP variability also tended to be greater in VSA patients. There was no difference in the HF-component coefficient of variance (CCV (%) = 100 x (component power) (1/2)/ mean RR intervals) of the RRI variabilities between the 2 groups. These results indicate that increased sympathetic vasomotor tone and cardiac sympathetic predominance may play an important role in patients with VSA.
F Yamasaki; T Sato; J Takata; T Chikamori; T Ozawa; M Sasaki; Y Doi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  60     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  10-6     Citation Subset:  IM    
Department of Clinical Laboratory, Kochi Medical School, Nankoku, Japan.
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MeSH Terms
Angina Pectoris, Variant / physiopathology*
Blood Pressure*
Circadian Rhythm
Heart Rate*
Middle Aged
Sympathetic Nervous System / physiopathology*

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