Document Detail

Sympathetic and haemodynamic responses to lipids in healthy human ageing.
MedLine Citation:
PMID:  20061355     Owner:  NLM     Status:  MEDLINE    
Plasma non-esterified fatty acids (NEFAs) activate the sympathetic nervous system and increase vascular resistance and blood pressure (BP); however, the response with ageing is not known. The objectives of this study were to characterize the cardiovascular, neural and endocrine responses to acute elevation of NEFA concentration. Seventeen healthy older volunteers (7 male and 10 female; age, 69 +/- 1 years; body mass index, 24 +/- 0 kg m(2); values are means +/- s.e.m.) received a 4 h intravenous infusion of the lipid emulsion Intralipid 20% or placebo (single-blind, randomized, balanced order) on two different days separated by at least 2 weeks. Muscle sympathetic nerve activity (MSNA), heart rate (HR), BP, cardiac output, leptin, insulin, aldosterone, angiotensin II and F(2)-isoprostanes were measured. The change in HR (+8.8 +/- 0.9 versus +3.0 +/- 0.9 beats min(1)), systolic BP (+13.9 +/- 2.2 versus +6.6 +/- 2.4 mmHg) and diastolic BP (+7.4 +/- 1.5 versus +1.3 +/- 0.8 mmHg) was significantly greater after Intralipid versus placebo infusions (P < 0.001). Lipid infusion increased MSNA burst frequency (+6.7 +/- 1.6 bursts min(1)), total MSNA (+45%; P < 0.001) and concentrations of insulin (+40%), aldosterone (+50%) and F(2)-isoprostanes (+80%), but not leptin. Hyperlipidaemia caused directionally opposite responses for insulin (increased) and calf vascular resistance (decreased) in men, whereas insulin and calf vascular resistance responses were severely blunted and non-existent, respectively, in women. We conclude that direct vascular mechanisms and central sympathetic activation contribute to the NEFA pressor response; though absolute values are higher, the change is not different compared with previous studies in a younger population.
John P Florian; James A Pawelczyk
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-01-08
Journal Detail:
Title:  Experimental physiology     Volume:  95     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  486-97     Citation Subset:  IM    
Intercollege Graduate Degree Program in Physiology and Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.
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MeSH Terms
Aging / blood*
Aldosterone / blood
Blood Pressure / drug effects,  physiology
Cardiac Output / drug effects
Epinephrine / blood
Fat Emulsions, Intravenous / pharmacology*
Fatty Acids, Nonesterified / blood*
Heart Rate / drug effects,  physiology
Hemodynamics / physiology*
Hyperlipidemias / physiopathology
Insulin / blood
Leg / blood supply
Leptin / blood
Middle Aged
Muscle, Skeletal / blood supply,  innervation
Regional Blood Flow
Sympathetic Nervous System / physiology*
Vascular Resistance / drug effects
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Leptin; 11061-68-0/Insulin; 51-43-4/Epinephrine; 52-39-1/Aldosterone

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