Document Detail

Sympathetic denervation of the iris dilator in noninsulin-dependent diabetes.
MedLine Citation:
PMID:  1787954     Owner:  NLM     Status:  MEDLINE    
Twenty-three subjects with noninsulin-dependent diabetes mellitus (NIDDM) and 23 age- and sex-matched controls were tested for sympathetic denervation of the iris dilator by comparing the mydriatic effect of the combination of 1% phenylephrine and 1% tropicamide with that of 1% tropicamide alone. Most of the diabetic subjects had no clinical signs of severe diabetic complications. Nine diabetics and two controls showed sympathetic denervation, defined as a 1 mm or greater dilation due the addition of 1% phenylephrine. One of those two controls had a recent history of vascular headache. The diabetics with pupillary neuropathy had higher glycosylated hemoglobin percentages and a history of higher fasting blood sugars (FBS's) than the diabetics with normal pupils. Our results show that pupillary neuropathy can develop in persons with diabetes, often before the other complications of diabetes become manifest.
G W Fulk; A Bower; K McBride; R Boatright
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Optometry and vision science : official publication of the American Academy of Optometry     Volume:  68     ISSN:  1040-5488     ISO Abbreviation:  Optom Vis Sci     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-26     Completed Date:  1992-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904931     Medline TA:  Optom Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  954-6     Citation Subset:  IM    
College of Optometry, Northeastern State University, Tahlequah, Oklahoma.
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MeSH Terms
Blood Glucose
Diabetes Mellitus, Type 2 / physiopathology*
Diabetic Neuropathies / diagnosis
Hemoglobin A, Glycosylated / metabolism
Iris / innervation*
Middle Aged
Nerve Degeneration*
Phenylephrine / administration & dosage
Random Allocation
Reflex, Pupillary
Tropicamide / administration & dosage
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 1508-75-4/Tropicamide; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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