Document Detail

Sympathetic control of metabolic and hormonal responses to exercise in rats.
MedLine Citation:
PMID:  654936     Owner:  NLM     Status:  MEDLINE    
The importance of the sympatho-adrenal system for the pancreatic hormonal response to exercise and, furthermore, the role of glucagon and catecholamines for the hepatic glycogen depletion during exercise were studied. Rats were either surgically adrenomedullectomized and chemically sympathectomized with 6-hydroxydopamine or shamtreated. Two weeks later the rats had either rabbit-antiglucagon serum or normal rabbit serum injected. Subsequently the rats either rested or swam with a tail weight for 75 min. Immediately afterwards cardiac blood was drawn and liver and muscle tissue collected. In control rats in spite of an increase in blood glucose concentrati4ns during exercise plasma insulin concentrations were unchanged, while glucagon concentrations increased. In sympathectomized rats, compared to control rats, glucagon concentrations increased less, and insulin concentrations were higher, although glucose concentrations were lower during exercise. Sympathectomy completely abolished the exercise-induced decrease in liver and muscle glycogen concentrations, whereas neither glycogen depletion nor plasma catecholamine concentrations were influenced by the administration of glucagon antibodies. These findings indicate that the sympatho-adrenal system enhances glucagon secretion as well as muscular and hepatic glycogen depletion but inhibits insulin secretion in exercising rats. The increase in glucagon concentrations, however, does not enhance hepatic glycogen depletion at the work load used.
H Galbo; E A Richter; N J Christensen; J J Holst
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  102     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  441-9     Citation Subset:  IM; S    
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MeSH Terms
Adrenal Medulla / physiology*
Epinephrine / metabolism
Glucagon / immunology
Glycogen / metabolism*
Hydroxydopamines / pharmacology
Immune Sera / pharmacology
Liver / metabolism*
Liver Glycogen / metabolism*
Muscles / metabolism*
Norepinephrine / metabolism
Pancreas / secretion*
Physical Exertion*
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Hydroxydopamines; 0/Immune Sera; 0/Liver Glycogen; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 9005-79-2/Glycogen; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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