Document Detail


Sympathetic control of the cerebral vasculature in humans.
MedLine Citation:
PMID:  20007920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them with responses in the forearm circulation.
METHODS: An oscillatory lower body negative pressure of 40 mm Hg was used at 6 frequencies from 0.03 to 0.08 Hz in 11 healthy subjects with and without alpha-adrenergic blockade by phentolamine.
RESULTS: Sympathetic blockade resulted in unchanged mean pressure and cerebral flow. The transfer function relationship to arterial pressure at frequencies >0.05 Hz was significantly increased in both the cerebral and brachial circulations, but the coherence of the relation remained weak at the lowest frequencies in the cerebral circulation.
CONCLUSIONS: Our data demonstrate a strong, frequency-dependent role for sympathetic regulation of blood flow in both cerebral and brachial circulations. However, marked differences in the response to blockade suggest the control of the cerebral circulation at longer time scales is characterized by important nonlinearities and relies on regulatory mechanisms other than the sympathetic system.
Authors:
J W Hamner; Can Ozan Tan; Kichang Lee; Michael A Cohen; J Andrew Taylor
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-12-10
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  41     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-29     Completed Date:  2010-01-28     Revised Date:  2013-08-28    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-9     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Adult
Cerebrovascular Circulation / drug effects,  physiology*
Female
Homeostasis / drug effects,  physiology
Humans
Male
Sympathetic Nervous System / drug effects,  physiology*
Ultrasonography, Doppler, Transcranial / methods
Young Adult
Grant Support
ID/Acronym/Agency:
HL093113/HL/NHLBI NIH HHS; R01 HL093113/HL/NHLBI NIH HHS; R01 HL093113-01A1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists
Comments/Corrections

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