Document Detail

Sympathetic cardiovascular hyperactivity precedes brain death.
MedLine Citation:
PMID:  20461435     Owner:  NLM     Status:  In-Process    
OBJECTIVE: The time preceding brain death is associated with complex dysregulation including autonomic dysfunction that may compromise organ perfusion, thus inducing final organ failure. In this study, we assessed autonomic function in patients prior to brain death.
METHODS: In 5 patients (2 women, median 60 years, age range 52-75 years) with fatal cerebral hemorrhage or stroke and negative prognosis, we monitored RR-intervals (RRI), systolic and diastolic blood pressure (BP), and oxygen saturation. Adjustment of mechanical ventilation remained constant. We assessed autonomic function from spectral powers of RRI and BP in the mainly sympathetic low- (LF, 0.04-0.15 Hz) and parasympathetic high-frequencies (HF, 0.15-0.5 Hz), and calculated the RRI-LF/HF-ratio as index of sympathovagal balance. Three patients required norepinephrine (0.5-1.6 mg/h) for up to 72 h to maintain organ perfusion. Norepinephrine was reduced to 0.2-0.5 mg/h within 2 h before brain death was diagnosed according to the criteria of the German Medical Association. Wilcoxon test compared average values of ten 2-min epochs determined 2-3 h (measurement 1) and 1 h (measurement 2) before brain death.
RESULTS: We found higher systolic (127.3 ± 15.9 vs. 159.4 ± 44.8 mmHg) and diastolic BP (60.1 ± 15.6 vs. 74.0 ± 15.2 mmHg), RRI-LF/HF-ratio (1.2 ± 1.6 vs. 3.9 ± 4.0), and BP-LF-powers (2.7 ± 4.8 vs. 23.1 ± 28.3 mmHg²) during measurement 2 than during measurement 1 (p < 0.05).
CONCLUSIONS: The increase in BPs, in sympathetically mediated BP-LF-powers, and in the RRI-LF/HF-ratio suggests prominent sympathetic activity shortly before brain death. Prefinal sympathetic hyperactivity might cause final organ failure with catecholamine-induced tissue damage which impedes post-mortem organ transplantation.
Harald Marthol; Tassanai Intravooth; Jürgen Bardutzky; Philip De Fina; Stefan Schwab; Max J Hilz
Related Documents :
19617255 - Autonomic nervous system and cardiovascular disease.
25197835 - Pressure induced manifold enhancement of li-kinetics in fcc fullerene.
7790285 - Baroreflex sensitivity during noxious stimulation in vasovagal reactors to blood donation.
9639375 - Myocyte recovery after mechanical circulatory support in humans with end-stage heart fa...
8272995 - Alterations in respiratory function and hemodynamics during laparoscopic cholecystectom...
11948385 - Accuracy of a new low-flow sidestream capnography technology in newborns: a pilot study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-12
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  20     ISSN:  1619-1560     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Insufficiency fracture at the distal diaphysis of the radius after synovectomy combined with the Sau...
Next Document:  Evaluation of the finger wrinkling test: a pilot study.