Document Detail


Sympathetic and cardiovascular activity during cataplexy in narcolepsy.
MedLine Citation:
PMID:  19021855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autonomic nervous system activity changes have been described during cataplexy as playing a role in triggering it. To confirm these previous findings, we investigated the time course of sympathetic and cardiovascular activities during cataplexy. We made for the first time microneurographic recordings of 10 cataplectic episodes in three patients with hypocretin-deficient narcolepsy. During microneurography, muscle sympathetic nerve activity (MSNA) was recorded simultaneously with heart rate (HR), respiratory movements, arterial finger blood pressure (BP), electroencephalography, electro-oculogram and superficial electromyogram. Results showed no significant autonomic changes before the onset of the cataplectic episodes. Cataplexy was associated with a significant increase in MSNA and BP compared with baseline, whereas HR was markedly decreased. An irregular breathing pattern mainly characterized by apnea typically occurred during the attacks. In conclusion, our findings did not show significant changes in autonomic activity prior to cataplexy onset, ruling out a triggering role of the autonomic system. However, cataplexy was associated with co-activation of sympathetic and parasympathetic autonomic systems, a pattern reminiscent of that reported during the vigilance reaction in animals.
Authors:
Vincenzo Donadio; Giuseppe Plazzi; Stefano Vandi; Christian Franceschini; Tomas Karlsson; Pasquale Montagna; Roberto Vetrugno; Enrico Bugiardini; Emmanuel Mignot; Rocco Liguori
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-20
Journal Detail:
Title:  Journal of sleep research     Volume:  17     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  458-63     Citation Subset:  IM    
Affiliation:
Department of Neurological Sciences, University of Bologna, Bologna, Italy. vincenzo.donadio@unibo.it
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Cataplexy / physiopathology*
Electrocardiography
Electroencephalography
Electromyography
Electrooculography
Heart Rate / physiology*
Humans
Intracellular Signaling Peptides and Proteins / deficiency
Male
Narcolepsy / metabolism,  physiopathology
Neuropeptides / deficiency
Sympathetic Nervous System / physiopathology*
Young Adult
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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