| Sympathetic autonomic dysfunction. Programmed subcutaneous noradrenaline administration via microdosing pump. | |
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MedLine Citation:
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PMID: 1812316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sympathetic dysfunction is characterized by postural hypotension, decreasing blood pressure without compensatory tachycardia during graded supine ergometric exercise, impaired catecholamine metabolism, and hypersensitivity to catecholamines. We report on eight patients, seven with sympathetic dysfunction, of whom three patients were treated for the first time with programmed subcutaneous noradrenaline administration by means of a microdosing pump over a time period of 1.5-13 months. A clear improvement in blood pressure values, orthostasis tolerance, and exercise capacity has been observed in these three patients which permit them to extend their action radius. Adjustment of the noradrenaline dose to the wide range of everyday stress and the possible occurrence of adrenoreceptor desensitization, however, remains a severe problem. |
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Authors:
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M Lehmann; K G Petersen; A N Khalaf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 69 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 872-9 Citation Subset: IM |
Affiliation:
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Abteilung für Sport- und Leistungsmedizin, Medizinische Universitätklinik Freiburg. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autonomic Nervous System Diseases / drug therapy*, etiology Blood Pressure / drug effects Catecholamines / blood Dose-Response Relationship, Drug Female Heart Rate / drug effects Humans Hypotension, Orthostatic / drug therapy, etiology Infusion Pumps, Implantable* Male Middle Aged Norepinephrine / administration & dosage* Recurrence Sympathetic Nervous System / drug effects* Syncope / drug therapy, etiology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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