Document Detail

Sympathetic adrenergic blockade effects upon operantly conditioned blood pressure elevations in baboons.
MedLine Citation:
PMID:  406939     Owner:  NLM     Status:  MEDLINE    
Sympathetic adrenergic nervous activity during operantly conditioned hypertension was evaluated by assessing the effects of specific alpha-(phentolamine or phenoxybenzamine) and beta- (propranolol) adrenergic blockers in baboons reinforced for increasing diastolic pressure in daily, 12-h sessions. In the first 10 min of control (no blockade) sessions, mean heart rate increased 24 bpm (21%) above the value for the 10 min immediately prior to the beginning of the sessions; systolic pressure increased 27 mm Hg (22%) and diastolic pressure increased 24 mm Hg (31%). Beta-blockade eliminated the tachycardia but did not attenuate the increased blood pressure. Alpha-blockade did not attenuate the increased blood pressure significantly either. Combined alpha- and beta-blockade did significantly attenuate the increase in diastolic pressure, but consistent, significant increases in systolic pressure (17 mm Hg, 17%) and diastolic pressure (16 mm Hg, 26%) still occurred. The results support the participation of the sympathetic adrenergic nervous system in producing operantly conditioned blood pressure changes, but the results are also consistent with the additional participation of nonadrenergic factors in operantly conditioned hypertension.
D S Goldstein; A H Harris; J V Brady
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biofeedback and self-regulation     Volume:  2     ISSN:  0363-3586     ISO Abbreviation:  Biofeedback Self Regul     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605548     Medline TA:  Biofeedback Self Regul     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-105     Citation Subset:  IM    
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MeSH Terms
Adrenergic Fibers / physiopathology*
Blood Pressure / drug effects
Conditioning, Operant*
Depression, Chemical
Heart Rate / drug effects
Hypertension / physiopathology*
Phenoxybenzamine / pharmacology
Phentolamine / pharmacology
Propranolol / pharmacology
Stimulation, Chemical
Reg. No./Substance:
50-60-2/Phentolamine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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