Document Detail


Sympathetic adrenergic blockade effects upon operantly conditioned blood pressure elevations in baboons.
MedLine Citation:
PMID:  406939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sympathetic adrenergic nervous activity during operantly conditioned hypertension was evaluated by assessing the effects of specific alpha-(phentolamine or phenoxybenzamine) and beta- (propranolol) adrenergic blockers in baboons reinforced for increasing diastolic pressure in daily, 12-h sessions. In the first 10 min of control (no blockade) sessions, mean heart rate increased 24 bpm (21%) above the value for the 10 min immediately prior to the beginning of the sessions; systolic pressure increased 27 mm Hg (22%) and diastolic pressure increased 24 mm Hg (31%). Beta-blockade eliminated the tachycardia but did not attenuate the increased blood pressure. Alpha-blockade did not attenuate the increased blood pressure significantly either. Combined alpha- and beta-blockade did significantly attenuate the increase in diastolic pressure, but consistent, significant increases in systolic pressure (17 mm Hg, 17%) and diastolic pressure (16 mm Hg, 26%) still occurred. The results support the participation of the sympathetic adrenergic nervous system in producing operantly conditioned blood pressure changes, but the results are also consistent with the additional participation of nonadrenergic factors in operantly conditioned hypertension.
Authors:
D S Goldstein; A H Harris; J V Brady
Related Documents :
3396239 - Systemic and coronary hemodynamic effects of combined oral alpha- and beta-adrenergic b...
11040229 - Transforming growth factor beta in hypertensives with cardiorenal damage.
2061869 - Hemodynamic effects of atropine, dobutamine, nitroprusside, phenylephrine, and proprano...
22299669 - Isoproterenol stress test during catheterization of patients with coarctation of the ao...
18346649 - Is beta-thalassemia trait a protective factor against ischemic cerebrovascular accidents?
3008709 - Signal transfer in cardiac muscle. alteration of the beta-adrenoceptor adenylate cyclas...
18195139 - Noninvasive ventilation in myasthenic crisis.
3472449 - Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt...
19871679 - The relative pressures within cutaneous lymphatic capillaries and the tissues.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biofeedback and self-regulation     Volume:  2     ISSN:  0363-3586     ISO Abbreviation:  Biofeedback Self Regul     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605548     Medline TA:  Biofeedback Self Regul     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-105     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / physiopathology*
Animals
Blood Pressure / drug effects
Conditioning, Operant*
Depression, Chemical
Haplorhini
Heart Rate / drug effects
Hypertension / physiopathology*
Male
Papio
Phenoxybenzamine / pharmacology
Phentolamine / pharmacology
Propranolol / pharmacology
Stimulation, Chemical
Chemical
Reg. No./Substance:
50-60-2/Phentolamine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Primary structure of tRNA Thr 1a and b from brewer's yeast
Next Document:  Diffusion of 133Xe through frog skins, toad bladders, and water boundary layers.