Document Detail

Sympathetic activity is not increased in L-NAME hypertensive rats.
MedLine Citation:
PMID:  19889865     Owner:  NLM     Status:  MEDLINE    
The role played by the sympathetic drive in the development of N(G)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension is not firmly established. Therefore, the present study was undertaken in conscious rats in which hypertension was induced by treatment with l-NAME over the course of either 2 or 14 days. Mean arterial pressure (MAP) was measured via a catheter placed in the femoral artery, drugs were administered via a cannula placed in the femoral vein, and renal sympathetic nerve activity (RSNA) was monitored using an implanted electrode. Despite the remarkable increase in arterial pressure, heart rate did not change after treatment with l-NAME. RSNA was similar in l-NAME-induced hypertensive rats treated over the course of 2 or 14 days, as well as in normotensive rats. It was also demonstrated that l-NAME-induced hypertensive rats displayed a resetting of the baroreflex control of RSNA to hypertensive levels, with decreased sensitivity over the course of 2 or 14 days. Furthermore, the sympathetic-vagal balance examined in the time and frequency domain and the renal and plasma norepinephrine content did not differ between groups. In conclusion, the evaluation of the sympathetic drive in conscious rats demonstrated that the arterial hypertension induced by l-NAME treatment over the course of 2 and 14 days does not show sympathetic overactivity.
Fernanda Machado Dos Santos; Daniel Penteado Martins Dias; Carlos Alberto Aguiar da Silva; Rubens Fazan; Helio Cesar Salgado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  298     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R89-95     Citation Subset:  IM    
Dept. of Physiology, School of Medicine of Ribeirão Preto, Univ. of São Paulo, Av. Bandeirantes, 3900, 14048-900 Ribeirão Preto-SP, Brazil.
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MeSH Terms
Baroreflex / physiology
Blood Pressure / physiology
Consciousness / physiology
Disease Models, Animal
Enzyme Inhibitors / adverse effects
Heart Rate / physiology
Hypertension / metabolism,  physiopathology*
Kidney / innervation*,  metabolism
NG-Nitroarginine Methyl Ester / pharmacology*
Norepinephrine / metabolism
Rats, Wistar
Sympathetic Nervous System / physiopathology*
Time Factors
Reg. No./Substance:
0/Enzyme Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-41-2/Norepinephrine

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