| Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. | |
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MedLine Citation:
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PMID: 21490214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ingestion of dietary fat stimulates production of the small-intestinal satiety factors oleoylethanolamide (OEA) and N-palmitoyl-phosphatidylethanolamine (NPPE), which reduce food intake through a combination of local (OEA) and systemic (NPPE) actions. Previous studies have shown that sympathetic innervation of the gut is necessary for duodenal infusions of fat to induce satiety, suggesting that sympathetic activity may engage small-intestinal satiety signals such as OEA and NPPE. In the present study, we show that surgical resection of the sympathetic celiac-superior mesenteric ganglion complex, which sends projections to the upper gut, abolishes feeding-induced OEA production in rat small-intestinal cells. These effects are accounted for by suppression of OEA biosynthesis, and are mimicked by administration of the selective β2-adrenergic receptor antagonist ICI-118,551. We further show that sympathetic ganglionectomy or pharmacological blockade of β2-adrenergic receptors prevents NPPE release into the circulation. In addition, sympathetic ganglionectomy increases meal frequency and lowers satiety ratio, and these effects are corrected by pharmacological administration of OEA. The results suggest that sympathetic activity controls fat-induced satiety by enabling the coordinated production of local (OEA) and systemic (NPPE) satiety signals in the small intestine. |
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Authors:
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Jin Fu; Nicholas V Dipatrizio; Ana Guijarro; Gary J Schwartz; Xiaosong Li; Silvana Gaetani; Giuseppe Astarita; Daniele Piomelli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-14 Completed Date: 2011-06-13 Revised Date: 2011-10-13 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 5730-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California 92697-4625, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Antagonists
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pharmacology Adrenergic beta-Agonists / pharmacology Amidohydrolases / metabolism Animals Chromatography, High Pressure Liquid Dietary Fats / pharmacology* Eating / drug effects, physiology Feeding Behavior / drug effects, physiology Food Ganglia, Sympathetic / physiology Ganglionectomy Intestine, Small / innervation*, physiology* Male Oleic Acids / metabolism, physiology* Phospholipase D / metabolism Propanolamines / pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta-2 / drug effects, physiology Satiety Response / drug effects Signal Transduction / physiology* Sympathectomy Sympathetic Nervous System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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5P30DK026687/DK/NIDDK NIH HHS; DK047208/DK/NIDDK NIH HHS; DK073955/DK/NIDDK NIH HHS; P30 DK026687-26/DK/NIDDK NIH HHS; R01 DK073955-02/DK/NIDDK NIH HHS; R01 DK073955-02S1/DK/NIDDK NIH HHS; R01 DK073955-03/DK/NIDDK NIH HHS; R01 DK073955-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Antagonists; 0/Adrenergic beta-Agonists; 0/Dietary Fats; 0/Oleic Acids; 0/Propanolamines; 0/Receptors, Adrenergic, beta-2; 0/oleoylethanolamide; 72795-19-8/ICI 118551; EC 3.1.4.4/Phospholipase D; EC 3.5.-/Amidohydrolases; EC 3.5.1.-/fatty-acid amide hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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