Document Detail

Sympathetic activation with desflurane in humans.
MedLine Citation:
PMID:  7873424     Owner:  NLM     Status:  MEDLINE    
Although the blood pressure lowering effects of desflurane and isoflurane were similar at equi-MAC, we noted a different pattern of response during intervals of rapidly increasing the inspired concentration of desflurane, when substantial increases in SNA, HR, and MAP occurred. Because of the lower potency of desflurane compared to isoflurane, higher concentrations of desflurane are necessary to establish an adequate surgical plane of anesthesia. Although clinically relevant concentrations of isoflurane did not trigger sympathetic activation, isoflurane triggered responses at an inspired concentration (approximately 5%) nearly equal to that of desflurane. The present research demonstrates that the initial exposure to desflurane in clinically relevant concentrations following anesthetic induction and the deepening of anesthesia with higher concentrations of desflurane can be profoundly sympatho-excitatory. Considerable caution should be taken when administering desflurane to patients who may be placed at risk by these responses.
T J Ebert; M Muzi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in pharmacology (San Diego, Calif.)     Volume:  31     ISSN:  1054-3589     ISO Abbreviation:  Adv. Pharmacol.     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-06     Completed Date:  1995-04-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9015397     Medline TA:  Adv Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-78     Citation Subset:  IM    
Department of Anesthesiology, Veterans Affairs Medical Center, Milwaukee, Wisconsin.
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MeSH Terms
Anesthetics / pharmacology*
Blood Pressure / drug effects
Heart Rate / drug effects
Isoflurane / analogs & derivatives*,  pharmacology
Sympathetic Nervous System / drug effects*,  physiology
Grant Support
Reg. No./Substance:
0/Anesthetics; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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