| Sympathetic renal innervation and resistant hypertension. | |
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MedLine Citation:
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PMID: 21331158 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Hypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. Several factors have been implicated in the pathogenesis of hypertension associated with renal disease and/or renal failure. Although the role of sodium retention, total body volume expansion, and hyperactivity of the renin-angiotensin-aldosterone system (RAAS) are well recognized, increasing evidence suggests that afferent impulses from the injured kidney may increase sympathetic nervous system activity in areas of the brain involved in noradrenergic regulation of blood pressure and contribute to the development and maintenance of hypertension associated with kidney disease. Recognition of this important pathogenic factor suggests that antiadrenergic drugs should be an essential component to the management of hypertension in patients with kidney disease, particularly those who are resistant to other modalities of therapy. |
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Authors:
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Vito M Campese; Elaine Ku; Jeanie Park |
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Publication Detail:
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Type: Journal Article Date: 2011-01-20 |
Journal Detail:
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Title: International journal of hypertension Volume: 2011 ISSN: 2090-0392 ISO Abbreviation: Int J Hypertens Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-18 Completed Date: 2011-07-14 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101538881 Medline TA: Int J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 814354 Citation Subset: - |
Affiliation:
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Division of Nephrology, USC/Keck School of Medicine, University of Southern California, 2020 Zonal Aveue, Los Angeles, CA 90033, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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