Document Detail

Sympathetic excitation during exercise as a cause of attenuated heart rate recovery in patients with myocardial infarction.
MedLine Citation:
PMID:  19443992     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart rate recovery (HRR) after exercise is known as a predictor of cardiac death in patients with heart disease. The mechanism is not fully understood, although a parasympathetic mechanism has been reported. To elucidate the factors that influence HRR, we evaluated the relationship of HRR with exercise performance and plasma norepinephrine (NE), lactic acid and B-type natriuretic peptide (BNP) responses to exercise testing.
METHODS: The study population consisted of 52 male patients (age 58 +/- 9.6 years) who had experienced myocardial infarction without residual ischemia, uncompensated heart failure or atrial fibrillation. All subjects underwent a symptom-limited cardiopulmonary exercise test without a cool-down period and echocardiography. NE, lactic acid and BNP were measured at rest and at peak exercise.
RESULTS: HRR did not correlate with the left ventricular ejection fraction, peak VO(2), lactic acid and BNP. HRR significantly correlated with the increment in heart rate (HR) from rest to peak exercise (DeltaHR) (r=0.30, p<0.05). When we divided DeltaHR into two phases at the anaerobic threshold (AT), HRR significantly correlated with DeltaHR (peak-AT) (r=0.409, p<0.01), but not with DeltaHR (AT-rest). There was a significant negative correlation between HRR and NE both at rest and at peak exercise (r=-0.286, p<0.05, r=-0.310, p<0.05). HRR was also correlated significantly with DeltaHR/logDeltaNE as an index of sensitivity to NE (r=0.421, p<0.01). Based on multiple regression analysis, DeltaHR and logDeltaNE predicted HRR (R(2)=0.467, p=0.0027).
CONCLUSIONS: Present findings suggest that enhanced sympathetic excitation at maximum exercise suppresses parasympathetic reactivation and results in attenuation of HRR.
Akiko Ushijima; Nagaharu Fukuma; Yuko Kato; Noriko Aisu; Kyoichi Mizuno
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi     Volume:  76     ISSN:  1345-4676     ISO Abbreviation:  J Nippon Med Sch     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-15     Completed Date:  2009-06-30     Revised Date:  2012-09-25    
Medline Journal Info:
Nlm Unique ID:  100935589     Medline TA:  J Nippon Med Sch     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  76-83     Citation Subset:  IM    
Division of Cardiology, Hepatology, Geriatrics, and Integrated Medicine, Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Down-Regulation / physiology
Exercise / physiology*
Exercise Test
Heart Rate*
Lactic Acid / blood
Middle Aged
Myocardial Infarction / radiotherapy*
Natriuretic Peptide, Brain / blood
Norepinephrine / blood
Parasympathetic Nervous System / physiology,  physiopathology
Sympathetic Nervous System / physiology*
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine

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