Document Detail


Sympathectomy or doxazosin, but not propranolol, blunt myocardial interstitial fibrosis in pressure-overload hypertrophy.
MedLine Citation:
PMID:  16216989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adaptive changes that develop in the pressure-overloaded left ventricular (LV) myocardium include cardiomyocyte hypertrophy and interstitial fibrosis. Although the former is known to depend to a sizeable extent on sympathetic (over)activity, little information exists whether the same applies to the latter, ie, whether excess catecholamine exposure contributes to the imbalance between collagen deposition by fibroblasts and degradation by matrix metalloproteases (MMPs), eventually leading to LV collagen accumulation. Sprague-Dawley rats were subjected to abdominal aortic banding (B) or sham operation (S) and treated with beta-blockade (Bb, oral propranolol, 40 mg/kg per day), chemical sympathectomy (Sx, 6-hydroxydopamine, 150 mg/kg intraperitoneal twice per week) or vehicle (Vh). Ten weeks later, systolic blood pressure, LV weight, collagen abundance (computer-aided histology), zymographic matrix metalloproteinase (MMP)-2 activity and its specific tissue inhibitor concentration (TIMP-2) were measured. Both sympathectomy and beta-blockade failed to attenuate the banding-induced blood pressure elevation but significantly attenuated the attendant LV hypertrophy. As expected, pressure-overload hypertrophy was associated with interstitial fibrosis (collagen: 4.37+/-1.23% BVh versus 1.23+/-0.44% SVh, P<0.05), which was abolished by sympathectomy (2.55+/-1.31%, P=not significant versus SSx) but left unchanged by beta-blockade (4.11+/-1.23%, P<0.05 versus both SBb and BSx). beta-blockade, but not sympathectomy, was also associated with an increased TIMP-2/MMP-2 ratio (P<0.05), indicating reduced interstitial collagenolytic activity. In separate groups of banded and sham-operated rats, treatment with the alpha-receptor blocker doxazosin (10 mg/kg per day) displayed similar antifibrotic and biochemical effects as sympathectomy. Thus in the course of experimental pressure overload, the sympathetic nervous system plays a major pro-fibrotic role, which is mediated via alpha-adrenergic but not beta-adrenergic receptors.
Authors:
Stefano Perlini; Giuseppina Palladini; Ivana Ferrero; Rossana Tozzi; Silvia Fallarini; Angelica Facoetti; Rosanna Nano; Francesca Clari; Giuseppe Busca; Roberto Fogari; Alberto U Ferrari
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Publication Detail:
Type:  Journal Article     Date:  2005-10-10
Journal Detail:
Title:  Hypertension     Volume:  46     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2005-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1213-8     Citation Subset:  IM    
Affiliation:
Clinica Medica II, IRCCS San Matteo, Università di Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology*
Adrenergic beta-Antagonists / pharmacology
Animals
Blood Pressure
Cardiomegaly / etiology*,  pathology*
Collagen / metabolism
Doxazosin / pharmacology*
Fibrosis
Hypertension / complications*,  physiopathology
Lung / physiopathology
Male
Matrix Metalloproteinase 2 / metabolism
Myocardium / metabolism,  pathology*
Propranolol / pharmacology
Rats
Rats, Sprague-Dawley
Sympathectomy, Chemical*
Tissue Inhibitor of Metalloproteinase-2 / metabolism
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 525-66-6/Propranolol; 74191-85-8/Doxazosin; 9007-34-5/Collagen; EC 3.4.24.24/Matrix Metalloproteinase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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