Document Detail

Sympathectomy and beta-adrenergic blockade during lung maturation stimulated by TRH and cortisol in fetal sheep.
MedLine Citation:
PMID:  8104175     Owner:  NLM     Status:  MEDLINE    
To test whether beta-adrenergic mechanisms and the sympathetic nervous system are involved in the synergistic action of thyrotropin-releasing hormone (TRH) and cortisol on lung maturation, fetal sheep (n = 32) were infused from 121 to 128 days of gestation with saline, TRH + cortisol, TRH + cortisol + beta-adrenergic blocker, or TRH + cortisol after chemical sympathectomy with 6-hydroxydopamine. TRH + cortisol increased lung distensibility and stability and alveolar concentrations of saturated phosphatidylcholine two- to threefold over control fetuses. beta-Adrenergic blockade prevented the increase in distensibility in response to TRH + cortisol. Sympathectomy did not impair the increase in distensibility and stability in response to TRH + cortisol but inhibited the increase in alveolar total phospholipids. Tissue concentrations of saturated phosphatidylcholine increased in TRH + cortisol-treated fetuses after either sympathectomy or beta-adrenergic blockade. We concluded that during lung maturation by TRH + cortisol 1) sympathetic mechanisms are requisite for surfactant release, 2) nonneurogenic beta-adrenergic mechanisms are requisite for the maturation of the mechanical properties of the lung and 3) stimulation of surfactant synthesis is independent of beta-adrenergic action and the sympathetic nervous system.
J C Schellenberg; G C Liggins; J A Kitterman; C C Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-19     Completed Date:  1993-10-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Auckland, New Zealand.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Blood Proteins / metabolism
Bronchoalveolar Lavage Fluid / metabolism
DNA / metabolism
Gestational Age
Hydrocortisone / blood,  pharmacology*
Lung / embryology*
Organ Size / physiology
Phosphatidylcholines / metabolism
Phospholipids / blood
Sympathectomy, Chemical*
Thyrotropin-Releasing Hormone / blood,  pharmacology*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Blood Proteins; 0/Phosphatidylcholines; 0/Phospholipids; 1199-18-4/Oxidopamine; 24305-27-9/Thyrotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 9007-49-2/DNA

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