Document Detail


Sympathectomy and beta-adrenergic blockade during lung maturation stimulated by TRH and cortisol in fetal sheep.
MedLine Citation:
PMID:  8104175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test whether beta-adrenergic mechanisms and the sympathetic nervous system are involved in the synergistic action of thyrotropin-releasing hormone (TRH) and cortisol on lung maturation, fetal sheep (n = 32) were infused from 121 to 128 days of gestation with saline, TRH + cortisol, TRH + cortisol + beta-adrenergic blocker, or TRH + cortisol after chemical sympathectomy with 6-hydroxydopamine. TRH + cortisol increased lung distensibility and stability and alveolar concentrations of saturated phosphatidylcholine two- to threefold over control fetuses. beta-Adrenergic blockade prevented the increase in distensibility in response to TRH + cortisol. Sympathectomy did not impair the increase in distensibility and stability in response to TRH + cortisol but inhibited the increase in alveolar total phospholipids. Tissue concentrations of saturated phosphatidylcholine increased in TRH + cortisol-treated fetuses after either sympathectomy or beta-adrenergic blockade. We concluded that during lung maturation by TRH + cortisol 1) sympathetic mechanisms are requisite for surfactant release, 2) nonneurogenic beta-adrenergic mechanisms are requisite for the maturation of the mechanical properties of the lung and 3) stimulation of surfactant synthesis is independent of beta-adrenergic action and the sympathetic nervous system.
Authors:
J C Schellenberg; G C Liggins; J A Kitterman; C C Lee
Related Documents :
9398705 - Seasonal variation in glucocorticoid activity in healthy men.
8672605 - Effects of ipsapirone on plasma cortisol and body temperature in major depression.
2560985 - The dexamethasone suppression test and long-term contraceptive treatment: measurement o...
1244745 - Cortisol in amniotic fluid and cord blood in relation to prenatal betamethasone load an...
18541395 - Comparative evaluation of postmortem serum concentrations of neopterin and c-reactive p...
22212595 - Amine oxidase activity of β-amyloid precursor protein modulates systemic and local cat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-19     Completed Date:  1993-10-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Auckland, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Animals
Blood Proteins / metabolism
Bronchoalveolar Lavage Fluid / metabolism
DNA / metabolism
Female
Gestational Age
Hydrocortisone / blood,  pharmacology*
Lung / embryology*
Organ Size / physiology
Oxidopamine
Phosphatidylcholines / metabolism
Phospholipids / blood
Pregnancy
Sheep
Sympathectomy, Chemical*
Thyrotropin-Releasing Hormone / blood,  pharmacology*
Grant Support
ID/Acronym/Agency:
HL-27356/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Blood Proteins; 0/Phosphatidylcholines; 0/Phospholipids; 1199-18-4/Oxidopamine; 24305-27-9/Thyrotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The affinity of ractopamine, clenbuterol, and L-644,969 for the beta-adrenergic receptor population ...
Next Document:  Fetal respiratory neuronal activity during REM and NREM sleep.