| Symmetrically dividing cells of the fission yeast schizosaccharomyces pombe do age. | |
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MedLine Citation:
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PMID: 16821114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theories of the evolution of senescence state that symmetrically dividing organisms do not senesce. However, this view is challenged by experimental evidence. We measured by immunofluorescence the occurrence and intensity of protein carbonylation in single and symmetrically dividing cells of Schizosaccharomyces pombe. Cells of S. pombe show different levels of carbonylated proteins. Most cells have little damage, a few show a lot, an observation consistent with the gradual accumulation of carbonylation over time. At reproduction, oxidized proteins are shared between the two resulting cells. These results indicate that S. pombe does age, but does so in a different way from other studied species. Damaged cells give rise to damaged cells. The fact that cells with no or few carbonylated proteins constitute the main part of the population can explain why, although age is not reset to zero in one of the cells during division, the pool of young cells remains large enough to prevent the rapid extinction of the population. |
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Authors:
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Nadège Minois; Magdalena Frajnt; Martin Dölling; Francesco Lagona; Matthias Schmid; Helmut Küchenhoff; Jutta Gampe; James W Vaupel |
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Publication Detail:
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Type: Journal Article Date: 2006-07-05 |
Journal Detail:
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Title: Biogerontology Volume: 7 ISSN: 1389-5729 ISO Abbreviation: Biogerontology Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-15 Completed Date: 2007-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930043 Medline TA: Biogerontology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 261-7 Citation Subset: IM |
Affiliation:
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Max Planck Institute for Demographic Research, Rostock, Germany. minois@imp.univie.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging
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physiology* Cell Division / physiology* Cell Proliferation Schizosaccharomyces / cytology*, physiology* Schizosaccharomyces pombe Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Schizosaccharomyces pombe Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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