Document Detail

Symmetrical thalamic degeneration with calcifications of infancy.
MedLine Citation:
PMID:  2672783     Owner:  NLM     Status:  MEDLINE    
We describe the clinical and radiographic features of three premature infants with symmetric thalamic calcification recognized by computed tomographic scan on days 6, 12, and 49 of life and contrast our findings with those reported in the literature. These lesions follow prepartum or intrapartum hypoxiaischemia and are clinically distinguished by prominent bulbar dysfunction, featuring weak or absent cry, poor feeding, and facial weakness. Neonatal thalamic calcification in premature infants may serve as a radiological marker of an acute, short-lived hypoxic-ischemic event. The presence of brain-stem dysfunction, particularly of lower cranial nerves in association with thalamic calcifications, constitutes a distinctive clinical-radiological entity and usually portends a poor outcome. The presence of these calcifications implies that injury was sustained to diencephalic and brain-stem structures at least 2 to 4 weeks prior to their appearance on computed tomographic scan.
F J DiMario; R Clancy
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  143     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-09-22     Completed Date:  1989-09-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1056-60     Citation Subset:  AIM; IM    
Department of Pediatrics and Neurology, University of Connecticut Health Center, University of Connecticut School of Medicine, Farmington 06032.
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MeSH Terms
Atrophy / complications,  congenital,  radiography
Calcinosis / complications,  congenital*,  radiography
Infant, Newborn
Infant, Premature, Diseases*
Motor Activity
Sucking Behavior
Thalamic Diseases / complications,  congenital*,  radiography
Thalamus / pathology*
Tomography, X-Ray Computed

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