| Symmetrical fetal growth retardation after gestational cocaine exposure in the rat. | |
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MedLine Citation:
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PMID: 15541849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cocaine use during pregnancy results in an increase in different maternal and perinatal complications. The fetal effects of cocaine could be mainly related to the disturbances in the brain development, microcephaly being the most common brain abnormality. The aim of this study was to analyze maternal outcome and fetal somatic effects of cocaine and to evaluate the hypothesis that maternal cocaine exposure would specifically impair fetal global brain development. Fifty-four timed-pregnant female Sprague-Dawley rats were daily injected with 15 or 40 mg/kg per day from gestational day (GD) 1 or 8 and sacrificed at gestational day 20. By analyzing different maternal and fetal outcomes, it could be suggested that the cocaine exposure in pregnant rats decreased maternal weight gain without significant maternal mortality, did not affect the mean number of fetuses by litter, although notably increased stillbirths, reduced fetal birth weight, and reduced the fetal central nervous system weight. Present results are globally in agreement with the literature and underline a possible selective effect of cocaine on the fetal CNS resulting in symmetrical intrauterine fetal growth retardation in contrast to the asymmetrical retardation of undernutrition. |
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Authors:
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F Campillo; M Remezal; M D Vez; J M Navarro-Pando; D Pérez-Flores; J J Parrilla; L Abad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 117 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-15 Completed Date: 2005-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 148-53 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects*, embryology Central Nervous System / drug effects, embryology Central Nervous System Diseases / chemically induced, embryology Central Nervous System Stimulants / adverse effects* Cocaine / adverse effects* Cocaine-Related Disorders / etiology Female Fetal Development / drug effects* Fetal Growth Retardation / chemically induced* Fetal Organ Maturity / drug effects Models, Animal Pregnancy Pregnancy Outcome Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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