Document Detail


Symmetrical fetal growth retardation after gestational cocaine exposure in the rat.
MedLine Citation:
PMID:  15541849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine use during pregnancy results in an increase in different maternal and perinatal complications. The fetal effects of cocaine could be mainly related to the disturbances in the brain development, microcephaly being the most common brain abnormality. The aim of this study was to analyze maternal outcome and fetal somatic effects of cocaine and to evaluate the hypothesis that maternal cocaine exposure would specifically impair fetal global brain development. Fifty-four timed-pregnant female Sprague-Dawley rats were daily injected with 15 or 40 mg/kg per day from gestational day (GD) 1 or 8 and sacrificed at gestational day 20. By analyzing different maternal and fetal outcomes, it could be suggested that the cocaine exposure in pregnant rats decreased maternal weight gain without significant maternal mortality, did not affect the mean number of fetuses by litter, although notably increased stillbirths, reduced fetal birth weight, and reduced the fetal central nervous system weight. Present results are globally in agreement with the literature and underline a possible selective effect of cocaine on the fetal CNS resulting in symmetrical intrauterine fetal growth retardation in contrast to the asymmetrical retardation of undernutrition.
Authors:
F Campillo; M Remezal; M D Vez; J M Navarro-Pando; D Pérez-Flores; J J Parrilla; L Abad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  117     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects*,  embryology
Central Nervous System / drug effects,  embryology
Central Nervous System Diseases / chemically induced,  embryology
Central Nervous System Stimulants / adverse effects*
Cocaine / adverse effects*
Cocaine-Related Disorders / etiology
Female
Fetal Development / drug effects*
Fetal Growth Retardation / chemically induced*
Fetal Organ Maturity / drug effects
Models, Animal
Pregnancy
Pregnancy Outcome
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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