| Symmetrical ambulatory arterial stiffness index: relationship with serum cystatin C levels. | |
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MedLine Citation:
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PMID: 21401347 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: Increased central arterial stiffening is the consequence of many disease states such as diabetes, atherosclerosis, and chronic renal disease. Symmetrical Ambulatory Arterial Stiffness Index (Sym-AASI) may provide a simple clinical approach to evaluate arterial stiffness. This study has tried to evaluate the relationship of Sym-AASI with cystatin C levels. Design and methods: The sample subjects were 53 males and 34 females (mean age = 59.3 ± 13.5 years). Kidney function was evaluated by measuring serum cystatin C and estimated glomerular filtration rate (eGFR). The ambulatory BP was measured noninvasively for 24 h. Results: Patients in the highest quartile showed an older age ( p < 0.001) and worse eGFR (p < 0.001). Pulse pressure (PP) increased as cystatin C was higher. Mean Sym-AASI showed an increase from the first to the last cystatin C quartile. Correlation test showed a significant relationship of Sym-AASI with age (r = 0.573), serum creatinine (r = 0.237), eGFR (-0.323), cystatin C (r = 0.427), systolic blood pressure (r = 0.525), and PP (r = 0.647). Multivariate regression analysis showed that age, cystatin C, nocturnal systolic blood pressure reduction, and nocturnal diastolic blood pressure fall were independently related to Sym-AASI. There was not any independent association between eGFR and Sym-AASI or between cystatin C and PP. Conclusions: Increased Sym-AASI seems to be independently associated with serum cystatin C levels. Sym-AASI seems to be better than PP to detect changes in the arterial wall. This could be a simple and easy method to evaluate arterial stiffness in hypertensive patients without needing more complex devices. |
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Authors:
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Nicolas Roberto Robles; Candido Mena; Josefa Martin de Prado; Francisco Garcia Gallego; Antonio Cidoncha; Julio Herrera |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 33 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Affiliation:
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Hypertension Unit, Hospital Infanta Cristina, Badajoz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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