| Symmetrical High Frequency Oscillation Increases Artificial Mucus Flow Without Changing Basal Mucus Transport in the in vitro Ovine Trachea. | |
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MedLine Citation:
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PMID: 21255499 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The efficacy of intraluminal high frequency oscillating (HFO) airflow is controversial and debated in the literature. Therefore experiments were carried out in vitro on abattoir-derived ovine tracheae to investigate the effects of symmetrical HFO on tracheal mucus transport following infusion of a layer of artificial mucus (polyox). Tracheae were mounted as intact tubes with a 15o head down tilt and 10 mL of artificial mucus infused caudally over one hour to simulate mucus production. Artificial mucus transport velocity (AMTV) was measured from the delay between the beginning of infusion to its first appearance over two near infrared sensors mounted at the rostral end of the preparation and by measuring the amount of mucus emerging. HFO (20Hz, 50cmH₂O) increased AMTV from 5.8 to 7.8 mm.min⁻ ¹. This led to nearly half the infused artificial mucus being cleared during the infusion period. In a second series of experiments the tracheae were opened flat and the epithelium viewed with a microscope. Video images of mucus movement were made through the microscope and endogenous mucus transport velocity (MTV) obtained by timing the movement of plaques in the endogenously-produced mucus sheet. The control MTV was 8.7 mm.min⁻ ¹ and HFO at either 14 or 20 Hz (50cmH₂O) did not significantly alter this. These experiments indicate that HFO can increase AMTV and mucus clearance when the thick layer of mucus is present. This may be significant when considering the mechanisms of mucus clearance and using intraluminal HFO as a means of clearing excessive mucus build up. |
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Authors:
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Stanislav Tatkov; Rodger J Pack |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-21 |
Journal Detail:
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Title: Respiratory care Volume: - ISSN: 0020-1324 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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