Document Detail

Symmetric focal degeneration in the cerebellar and vestibular nuclei in swine caused by ingestion of Aeschynomene indica seeds.
MedLine Citation:
PMID:  12724573     Owner:  NLM     Status:  MEDLINE    
A vestibulocerebellar disorder was observed in 2- to 4-month-old swine after consumption of broken rice contaminated with 13% Aeschynomene indica seeds. Affected animals recovered in 2-14 days after removal of the contaminated food. To reproduce the syndrome, 10 pigs were fed 13% A. indica seeds in commercial pig ration or rice. They showed clinical signs similar to those observed in the spontaneous cases, 1 hour to 6 days after ingestion. Three pigs recovered after the withdrawal of the contaminated food. The others were killed. Two pigs that were fed for 25 days with food containing 3% and 6% seeds and two control pigs did not show clinical signs. Histologic lesions were characterized by symmetric focal degeneration in the cerebellar and vestibular nuclei. The initial lesion, observed 24 hours after the first ingestion, was characterized by vacuolation of the neuropil. Subsequently, there was progressive loss of parenchyma, vascular reaction, a few small spheroids, astrocytosis, and accumulation of gitter cells. The brains from four pigs were perfused with a buffered solution of glutaraldehyde-paraformaldehyde 12-48 hours after they started to ingest the seeds. No ultrastructural lesions were observed in the cerebellar nuclei after 12 hours of seed consumption. At 24 hours, endothelial cells and pericytes were separated by empty spaces from astrocyte foot processes, suggesting perivascular edema. The astrocytes were enlarged, consistent with intracellular fluid accumulation. These results suggest that A. indica seeds are toxic, causing functional derangement of the vestibulocerebellar system, followed by alterations in the microvasculature in the cerebellar and vestibular nuclei.
F Riet-Correa; C D Timm; S S Barros; B A Summers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary pathology     Volume:  40     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-01     Completed Date:  2003-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Veterinary Faculty, Federal University of Campina Grande, Campus de Patos, Paraíba, Brazil.
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MeSH Terms
Brain / pathology,  ultrastructure
Cerebellar Diseases / metabolism,  pathology,  veterinary*
Fabaceae / toxicity*
Histocytochemistry / veterinary
Microscopy, Electron / veterinary
Plant Poisoning / metabolism,  pathology,  veterinary*
Seeds / toxicity*
Swine Diseases / etiology*,  metabolism,  pathology*
Vestibular Diseases / metabolism,  pathology,  veterinary*

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