Document Detail


Symmetric cell division of the mouse zygote requires an actin network.
MedLine Citation:
PMID:  22887777     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Positioning of the cleavage plane is regulated to ensure proper animal development. Most animal cells rely on the astral microtubules to position the mitotic spindle, which in turn specifies the cleavage plane. The mouse zygote lacks discernible astral microtubules but still divides symmetrically. Here, we demonstrate a cloud-like accumulation of F-actin surrounds the spindle in zygotes and when this actin network is disassembled, the spindle assumes an off-center position, and the resulting zygote divides asymmetrically into two unequal size blastomeres. Interestingly, when the spindle is micromanipulated to the sub-cortical region, the zygote without the actin network is unable to re-position the spindle and cleavage plane at the cell center. This study reveals that an actin network maintains the central spindle position in anastral mitosis, and ensures the first embryonic mitosis is symmetrical. © 2012 Wiley-Blackwell, Inc.
Authors:
Ting Gang Chew; Chanchao Lorthongpanich; Wei Xia Ang; Barbara B Knowles; Davor Solter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-6
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  -     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Mammalian Development Laboratory, Institute of Medical Biology, A-STAR, Singapore. tinggang80@gmail.com.
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