Document Detail

Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells.
MedLine Citation:
PMID:  11165236     Owner:  NLM     Status:  MEDLINE    
Syk has been implicated in activated immunoreceptors to downstream signaling events in hematopoietic cells. Here we report that Syk is expressed in neuron-like cells and involved in neuron-like differentiation of embryonal carcinoma P19 cells. Immunoblot, RT-PCR, and Northern analysis indicated that Syk is expressed in mouse brain, PC12 and P19 cells. In addition, Syk was found to be tyrosine phosphorylated during neuron-like differentiation of P19 cells. Furthermore, adenovirus-mediated overexpression of Syk induced supernumerary neurite formation and extracellular signal-regulated kinase (ERK) activation in P19 cells. These results suggest that Syk plays an important role in signaling steps leading to ERK activation in P19 cells.
T Tsujimura; S Yanagi; R Inatome; T Takano; I Ishihara; N Mitsui; S Takahashi; H Yamamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  489     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-15     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Department of Biochemistry, Kobe University School of Medicine, Chuo-ku, 650-0017, Kobe, Japan.
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MeSH Terms
Adenoviridae / genetics
Brain / cytology,  enzymology
Carcinoma, Embryonal / enzymology*,  pathology
Cell Differentiation*
DNA, Recombinant
Enzyme Activation
Enzyme Precursors / genetics,  metabolism*
Gene Expression Regulation, Enzymologic
Intracellular Signaling Peptides and Proteins
Mitogen-Activated Protein Kinases / metabolism
Neurites / metabolism
Neurons / cytology*,  enzymology
Protein-Tyrosine Kinases / genetics,  metabolism*
RNA, Messenger / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Tyrosine / metabolism
Reg. No./Substance:
0/DNA, Recombinant; 0/Enzyme Precursors; 0/Intracellular Signaling Peptides and Proteins; 0/RNA, Messenger; 55520-40-6/Tyrosine; EC Kinases; EC kinase; EC Protein Kinases

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