Document Detail

Switching to an L/N-type Calcium Channel Blocker Shows Renoprotective Effects in Patients with Chronic Kidney Disease: the Kyoto Cilnidipine Study.
MedLine Citation:
PMID:  22971493     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: This open-label, randomized controlled trial investigated the effects of cilnidipine, an L/N-type calcium channel blocker (CCB), in patients with chronic kidney disease (CKD).
METHODS: Sixty patients with CKD and well-controlled hypertension being treated with a renin- angiotensin system (RAS) inhibitor and an L-type CCB (L-CCB) were randomly assigned either to switch from the L-CCB to cilnidipine after a 4-week observation period or to continue with L-CCB treatment. Blood pressure, heart rate and renal function were monitored for 12 months. Data were available for analysis from 50 patients: 24 from the cilnidipine group and 26 from the L-CCB group.
RESULTS: Blood pressure was well controlled in both groups. After 12 months, proteinuria and heart rate were significantly decreased in the cilnidipine group, but proteinuria increased and heart rate remained unchanged in the L-CCB group. There was a significant positive correlation between the percentage changes in proteinuria and heart rate.
CONCLUSIONS: Cilnidipine has antihypertensive effects equivalent to those of L-CCBs. In patients with CKD, proteinuria can be decreased by switching from an L-CCB to cilnidipine, thereby improving renal function.
T Hatta; K Takeda; Y Shiotsu; C Sugishita; T Adachi; T Kimura; K Sonomura; T Kusaba; N Kishimioto; H Narumiya; S Tanda; K Tamagaki; K Yamada; H Kameyama; H Kido; S Harada; Y Bito; J Moriguchi; S Morimoto; M Okigaki; H Itoh; Y Mori; T Nakata; K Maki; S Sasaki; K Sawada; H Matsubara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  40     ISSN:  1473-2300     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1417-28     Citation Subset:  IM    
Department of Medicine, Division of Hypertension and Nephrology, Omihachiman Community Medical Centre, 1379 Tsuchida-cho, Omihachiman City, Shiga 523-0082, Japan.
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