| Switching to Raltegravir in Virologically Suppressed in HIV-1-Infected Patients: A Retrospective, Multicenter, Descriptive Study. | |
| | |
MedLine Citation:
|
PMID: 23061598 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objectives: To describe the efficacy and tolerability of switching to raltegravir (RAL) in virologically suppressed HIV-1-infected patients during routine clinical practice. Methods: A total of 263 subjects (189 men, median age 48.1 years) with HIV-1 RNA < 50 copies/mL for ≥ 6 months were switched to RAL (400 mg b.i.d). Reasons for change were toxicity (49.0%), drug interactions (6.1%) or convenience (28.6%) (switch from subcutaneous to oral treatment 22.4%, improvement of posology 3.4%). Patients were followed up to 24 months after switching to RAL. Primary end-points were tolerability and virological failure defined as two consecutive measures of HIV-1 RNA > 50 copies/mL. Results: After a median of 12.4 months (range 2.8-26.4 months), virological failure was observed in 6 (2.3%) patients (2.2 per 100 person-years,[95%CI 0.9-4.6]), while AIDS occurred in 1, drug discontinuation in 4, 3 patients died and 10 were lost to follow-up. The median CD4+ T cell count increased from 460 cells/mm3 to 508.6 cells/mm3 (P < 0.001). Conclusions: Switching to RAL in clinical practice was mainly driven by toxicity, convenience or interactions, they were well tolerated and secured virologic suppression in the vast majority of patients. |
| | |
Authors:
|
Daniel Podzamczer; Esteban Martínez; Pere Domingo; Elena Ferrer; Pompeyo Viciana; Jordi Curto; Maria-Jesús Pérez-Elías; Antonio Ocampo; Ignacio Santos; Hernando Knobel; Vicente Estrada; Eugenia Negredo; Ferrán Segura; Joaquín Portilla; Esteban Ribera; Josefa Galindo; Antonio Antela; Jorge Carmena; Manuel Castaño |
Related Documents
:
|
18430338 - A significant reduction in paediatric post-tonsillectomy vomiting through audit. 9876788 - Propofol maintenance to reduce postoperative emesis in thyroidectomy patients: a group ... 18257398 - Lorazepam, diphenhydramine, and haloperidol transdermal gel for rescue from chemotherap... 267658 - Character and frequency of discomfort immediately following restorative procedures. 2196078 - Side-effects of psoralen photochemotherapy (puva). 21467908 - A long-term follow-up study of acellular dermal matrix with thin autograft in burns pat... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-04 |
Journal Detail:
|
Title: Current HIV research Volume: - ISSN: 1873-4251 ISO Abbreviation: Curr. HIV Res. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101156990 Medline TA: Curr HIV Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
HIV Unit, Infectious Disease Service, Hospital Universitari de Belvitge, C/Feixa Llarga s/n, E-08907 L'Hospitalet de Llobregat, Barcelona, Spain. dpodzamczer@bellvitgehospital.cat. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Colectomy with ileorectal anastomosis has a worse 30 day outcome when performed for colonic inertia ...
Next Document: The Effect of Unsuccessful Treatment with Peginterferon and Ribavirin on the Liver Fibrosis Course o...