| Switching of chromatin-remodelling complexes for oestrogen receptor-alpha. | |
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MedLine Citation:
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PMID: 18451880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERalpha at G2/M was lowered. Biochemical approaches showed that ERalpha associated with two discrete classes of ATP-dependent chromatin-remodelling complex in a cell-cycle-dependent manner. The components of the NuRD-type complex were identified as G2/M-phase-specific ERalpha co-repressors. Thus, our results indicate that the transactivation function of ERalpha is cell-cycle dependent and is coupled with a cell-cycle-dependent association of chromatin-remodelling complexes. |
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Authors:
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Maiko Okada; Shin-ichiro Takezawa; Yoshihiro Mezaki; Ikuko Yamaoka; Ichiro Takada; Hirochika Kitagawa; Shigeaki Kato |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-02 |
Journal Detail:
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Title: EMBO reports Volume: 9 ISSN: 1469-3178 ISO Abbreviation: EMBO Rep. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-09-17 Revised Date: 2011-04-21 |
Medline Journal Info:
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Nlm Unique ID: 100963049 Medline TA: EMBO Rep Country: England |
Other Details:
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Languages: eng Pagination: 563-8 Citation Subset: IM |
Affiliation:
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The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology* Cell Line Chromatin / metabolism* Chromatin Assembly and Disassembly* Estrogen Receptor alpha / genetics, metabolism* Estrogens / metabolism Female Humans Macromolecular Substances / metabolism* Transcriptional Activation |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Estrogen Receptor alpha; 0/Estrogens; 0/Macromolecular Substances; 0/estrogen receptor alpha, human |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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