Document Detail

Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial.
MedLine Citation:
PMID:  18183545     Owner:  NLM     Status:  MEDLINE    
Veterinarians currently have a choice of six registered NSAIDs for use in the management of canine osteoarthritis. There is a need for data to clarify whether there is an increased risk of side effects occurring in the event of a switch between different members of the NSAID class. In this retrospective analysis of extensive data collected in the 1,000 dog Previcox (firocoxib, Merial) Experience Trial, the incidence of side effects in dogs reported as treated with an NSAID 7 days or less before enrollment was compared with that in dogs reported as not having received an NSAID in the equivalent period. Statistical analysis of the data indicates that observation of an interval of up to 1 week between beginning treatment with firocoxib and cessation of treatment with a different NSAID was not associated with any increased risk of adverse events.
William G Ryan; Katherine Moldave; Doug Carithers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary therapeutics : research in applied veterinary medicine     Volume:  8     ISSN:  1528-3593     ISO Abbreviation:  Vet. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-09     Completed Date:  2008-02-28     Revised Date:  2012-10-26    
Medline Journal Info:
Nlm Unique ID:  100936368     Medline TA:  Vet Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Ryan Mitchell Associates LLC, Westfield, NJ 07090, USA.
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MeSH Terms
4-Butyrolactone / administration & dosage,  adverse effects,  analogs & derivatives,  therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects,  therapeutic use*
Clinical Trials as Topic / veterinary*
Databases, Factual
Drug Administration Schedule
Osteoarthritis / drug therapy*,  pathology
Patient Selection
Research Design
Retrospective Studies
Sulfones / administration & dosage,  adverse effects,  therapeutic use
Veterinary Drugs / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Sulfones; 0/Veterinary Drugs; 189954-96-9/firocoxib; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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